Efficacy and safety of combination therapy with latanoprost after a change in therapeutic regimen from timolol to brinzolamide in Japanese adult patients with primary open-angle glaucoma and ocular hypertension: open, non-randomized 12-week study

Figures & data

Figure 1 Change in IOP after regimen change. (**p < 0.05, Wilcoxon signed rank test).

Figure 2 Change in IOP reduction rate after regimen change. Average IOP reduction rate 12 weeks after regimen change was 7.3%.

Table 1 Patients

Glaucoma diagnosis
Primary open angle glaucoma	17 eyes
Ocular hypertension	3 eyes
Female: Male	9: 11
Age (Mean ± standard deviation)	64.5 ± 11.0 years

Figure 3 Change in blood pressure after regimen change. No significant differences were seen in blood pressure (p > 0.05, Wilcoxon signed rank test).

Figure 4 Change in pulse rate after regimen change. The pulse rate was significantly increased 12 weeks after substituting brinzolamide compared with baseline with timolol (*p < 0.01, Wilcoxon signed rank test).

Table 2 Ocular discomfort

Blurring	2 eyes (10%)
Irritation (mild)	1 eye (5%)
Hyperemia (mild)	1 eye (5%)

Systemic adverse events were not observed.