Correlation of central corneal thickness and axial length to the optic disc and peripapillary atrophy among healthy individuals, glaucoma and ocular hypertension patients

Figures & data

Table 1 Demographics and Inclusion criteria

	Group A (Healthy)	Group B (POAG)	Group C (OH)
Number of eyes	30	30	30
Sex(m/f)	15/15	15/15	15/15
Age (mean-range)	50.7 (43–76)	58.8 (46–79)	55.6 (41–72)
IOP (mmHg)	≤21	>21	>21
VF	Normal	Abnormal	Normal
Risk factors	–	±	–

Table 2 Risk factors associated with increased prevalence of glaucoma damage

IOP > 21 mmHg

Positive family history

Race (African-Americans)

High myopia

Diabetes

High blood pressure

Steroid use

Figure 1 Optic disc and peripapillary atrophy.

Figure 2 Mapping of cupping, disc and peripapillary atrophy.

Figure 3 Cupping area (C).

Figure 4 Disc area (D).

Figure 5 Peripapillary atrophy (PPA).

Table 3 Descriptive statistics

	GROUP	Mean	Std. deviation	Min	Max
CCT (μm)	Normal	561,10	31,06	496	602
	POAG	551,63	34,96	495	605
	OH	559,63	35,48	497	600
AXL (mm)	Normal	23,78	1,42	21,78	26,65
	POAG	23,39	1,13	21,48	26,18
	OH	23,63	1,21	21,88	26,54
PPA (μm^2)	Normal	340,02	138,66	153	627
	POAG	358,43	130,43	205	651
	OH	305,72	93,77	173	525
C/D area	Normal	0,263	0,089	0,100	0,469
	POAG	0,383	0,172	0,110	0,690
	OH	0,326	0,163	0,100	0,744
PPA/D area	Normal	0,237	0,128	0,109	0,599
	POAG	0,254	0,142	0,130	0,842
	OH	0,220	0,107	0,115	0,596
D (μm^2)	Normal	1525,14	261,29	875,52	2026,79
	POAG	1489,47	257,67	772,57	2383,84
	OH	1473,10	222,58	880,87	1883,53

Table 4 Intergroup variation (ANOVA)

Dependent variable	(I) Group	(J) Group	Mean difference (I–J)	Sig (p)	95% confidence interval
					Lower bound	Upper bound
CCT	Normal	POAG	9,47	0,282	−7,93	26,86
		OH	1,47	0,867	−15,93	18,86
	POAG	Normal	−9,47	0,282	−26,86	7,93
		OH	−8,00	0,363	−25,39	9,39
	OH	Normal	−1,47	0,867	−18,86	15,93
		POAG	8,00	0,363	−9,39	25,39
AXL	Normal	POAG	0,42	0,212	−0,25	1,11
		OH	0,26	0,449	−0,49	0,91
	POAG	Normal	−0,42	0,212	−1,11	0,25
		OH	−0,2	0,621	−0,8	0,47
	OH	Normal	−0,26	0,449	−0,91	0,49
		POAG	0,2	0,621	−0,47	0,8
PPA	Normal	POAG	−18,42	0,562	−81,29	44,46
		OH	34,30	0,281	−28,58	97,18
	POAG	Normal	18,42	0,562	−44,46	81,29
		OH	52,72	0,099	−10,16	115,59
	OH	Normal	−34,30	0,281	−97,18	28,58
		POAG	−52,72	0,099	−115,59	10,16
C/D area	Normal	POAG	−0,119	0,002(*)	−0,194	−0,044
		OH	−0,062	0,101	−0,137	0,012
	POAG	Normal	0,119	0,002(*)	0,044	0,194
		OH	0,056	0,137	−0,018	0,131
	OH	Normal	0,062	0,101	−0,012	0,137
		POAG	−0,056	0,137	−0,131	0,018
PPA/D area	Normal	POAG	−0,017	0,600	−0,082	0,047
		OH	0,016	0,611	−0,048	0,082
	POAG	Normal	0,017	0,600	−0,047	0,082
		OH	0,034	0,303	−0,031	0,099
	OH	Normal	−0,016	0,611	−0,082	0,048
		POAG	−0,034	0,303	−0,099	0,031
D	Normal	POAG	35,67	0,579	−91,49	162,84
		OH	52,04	0,418	−75,12	179,21
	POAG	Normal	−35,67	0,579	−162,84	91,49
		OH	16,37	0,799	−110,80	143,54
	OH	Normal	−52,04	0,418	−179,21	75,12
		POAG	−16,37	0,799	−143,54	110,80

* Note: The mean difference is significant at the 0.05 level.

Figure 6 Relationship between AXL and D in Group A (healthy eyes).

Figure 7 Relationship between CCT and C/D area in Group B (POAG eyes).

Figure 8 Relationship between PPA and D in Group C (OH eyes).