A comfort comparison of travoprost BAK-free 0.004% versus latanoprost 0.005% in patients with primary open-angle glaucoma or ocular hypertension

Figures & data

Table 1 Patient characteristics

Characteristic	N	Percentage
A. Gender
Female	37	68.5%
Male	17	31.5%
B. Race
Caucasian	42	77.8%
Black	9	16.7%
Hispanic	2	3.7%
Middle Eastern	1	1.9%
C. Iris color
Hazel	24	44.4%
Brown	20	37.0%
Green	6	11.1%
Blue	4	7.4%
D. Medical history
Cardiovascular arterial hypertension	39	72.2%
Cardiovascular lipid disorders	25	46.3%
Endocrine diabetes	19	35.2%
E. Opthalmic history
Primary open-angle glaucoma	35	64.8%
Ocular hypertension	16	29.6%
Pigmentary glaucoma	3	5.6%
F. Glaucoma medication history
Latanoprost 0.005%	29	35.2%
Travoprost 0.004%	18	33.3%
Bimatoprost 0.03%	6	11.1%
Mean number of glaucoma medications	1.82
Mean time on glaucoma medications (in years)	12.56
G. Eyes assigned to each medicine
	OD
Test medication
Latanaprost	25	46.3%
Travaprost BAK-free	29	53.7%
	OS
Latanaprost	29	53.7%
Travaprost BAK-free	25	46.3%

Table 2 Mean post-dosing readings on the product preference scale

Time (seconds)	N	Mean
		Latanoprost	Travoprost BAK-free	P-value
5	54	7.1 ± 16.2	7.8 ± 16.1	0.53
10	54	6.8 ± 15.4	7.4 ± 15.8	0.55
15	54	7.0 ± 15.2	7.2 ± 15.3	0.84
20	54	6.8 ± 15.2	7.3 ± 15.2	0.58
25	54	6.8 ± 15.2	7.0 ± 15.2	0.81
30	54	7.0 ± 15.5	6.7 ± 15.0	0.73
35	54	7.0 ± 15.5	6.4 ± 15.0	0.40
40	54	6.8 ± 15.2	6.4 ± 15.0	0.47
45	54	6.8 ± 15.2	6.4 ± 15.0	0.47
50	54	6.8 ± 15.2	6.7 ± 15.1	0.90
55	54	6.8 ± 15.2	6.6 ± 15.1	0.80
60	54	6.8 ± 15.2	6.6 ± 15.1	0.71
120	54	7.2 ± 15.3	7.6 ± 16.4	0.78
300	54	6.9 ± 15.2	7.2 ± 15.9	0.80
600	54	6.9 ± 15.2	6.5 ± 15.4	0.61
900	54	6.8 ± 15.2	5.7 ± 15.1	0.06
1200	54	6.8 ± 15.2	5.7 ± 15.1	0.06
1800	54	6.7 ± 15.2	5.8 ± 15.1	0.11
Peak	54	8.4 ± 16.5	10.5 ± 17.0	0.21
Return to baseline (seconds)	54	16.8 ± 84.1	6.7 ± 23.7	0.41

Table 3 Comfort survey results

Time (seconds)	Baseline	Latanoprost		Travoprost BAK-free
	Mean	Mean	P-value	Mean	P-value
NPCS burning	7.5 ± 15.9	8.4 ± 16.5	0.37	10.5 ± 17.0	0.06
NPCS stinging	0.2 ± 0.8	0.1 ± 0.7	0.18	0.1 ± 0.7	0.18
NPCS foreign body	0.04 ± 0.3	0.02 ± 0.1	0.32	0.02 ± 0.1	0.32
NPCS general discomfort	0.1 ± 1.0	0.02 ± 0.1	0.40	0.02 ± 0.1	0.40
NPCS overall accept	0.5 ± 1.1	0.2 ± 0.7	0.04	0.3 ± 1.1	0.30

Abbreviation: NPCS, Nine Point Comfort Survey.