Role of fixed-combination brinzolamide 1%/timolol 0.5% in the treatment of elevated intraocular pressure in open-angle glaucoma and ocular hypertension

Figures & data

Table 1 Run-in medication, treatment combination after adding brinzolamide, baseline characteristics, time point(s) of intraocular pressure measurements and absolute (mmHg) and relative (%) decrease from baseline intraocular pressure for peak and trough time points

Trial	Run-in medication	Treatment combination after run-in	No. of patients baseline (% withdrawals)	Sex (M/F)	Mean age (y)	POAG (%)	OHT (%)	Endpoint of measurement (months)	Baseline IOP (mmHg) mean ± SD	Time point(s) of IOP measurements	IOP decrease (mmHg) mean ± SD	IOP decrease (%) mean ± SD
Trough
Shin 2000^Citation54	0.5% timolol bid	0.5% timolol bid and 1% brinzolamide tid	53 (11.3)	28/25	61	59	41	1	25.5 ± nr	+0 timolol +0 brinzolamide	–3.3 ± nr	–13.2 ± nr
Michaud et al 2001^Citation55	0.5% timolol bid	0.5% timolol bid and 1% brinzolamide tid	104 (6.7)	54/50	nr	57	37	1	25.5 ± 1.9	+0 timolol +0 brinzolamide	–3.6 ± 3.0	–14.1 ± 11.4
Martinez et al 2009^Citation56	0.5% timolol bid	0.5% timolol bid and 1% brinzolamide tid	76 (54)	41/35	64	100	0	60	22.7 ± 1.2	nr	–4.3 ± nr	–18.9 ± nr
Kaback et al 2008^Citation57	washout	0.5% timolol/1% brinzolamide bid (fixed)	171 (7.5)	80/91	nr	63	37	3	27.1 ± 2.7	+0 timolol +0 brinzolamide	–8.3 ± 3.8	–30.6 ± 13.6
Manni et al 2009^Citation58	washout	0.5% timolol/1% brinzolamide bid (fixed)	220 (7.3)	96/124	65	78	22	3	27.3 ± nr	+0 timolol +0 brinzolamide	–9.1 ± nr	–33.3 ± nr
Peak
Shin 2000^Citation54	0.5% timolol bid	0.5% timolol bid and 1% brinzolamide tid	53 (11.3)	28/25	61	59	41	1	25.5 ± nr	+0 timolol +0 brinzolamide	–3.3 ± nr	–14.3 ± nr
Michaud et al 2001^Citation55	0.5% timolol bid	0.5% timolol bid and 1% brinzolamide tid	104 (6.7)	54/50	nr	57	37	1	25.5 ± 1.9	+0 timolol +0 brinzolamide	–4.9 ± 2.6	–20.3 ± 10.5
Martinez et al 2009^Citation56	0.5% timolol bid	0.5% timolol bid and 1% brinzolamide tid	76 (54)	41/35	64	100	0	60	22.7 ± 1.2	nr	–4.3 ± nr	–18.9 ± nr
Kaback et al 2008^Citation57	washout	0.5% timolol/1% brinzolamide bid (fixed)	171 (7.5)	80/91	nr	63	37	3	25.8 ± 3.0	+0 timolol +0 brinzolamide	–8.7 ± 3.9	–33.7 ± 14.7
Manni et al 2009^Citation58	washout	0.5% timolol/1% brinzolamide bid (fixed)	220 (7.3)	96/124	65	78	22	3	25.9 ± nr	+0 timolol +0 brinzolamide	–9.1 ± nr	–34.9 ± nr

Abbreviations: M, male; F, female; Y, year; POAG, primary open-angle glaucoma; OHT, ocular hypertension; IOP, intraocular pressure; SD, standard deviation; bid, twice daily; tid, thrice daily; nr, not reported.

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