Oral versus topical carbonic anhydrase inhibitors in ocular hypertension after scleral tunnel cataract surgery

Figures & data

Table 1 Patient characteristics

Character	Control group	Acetazolamide group	Dorzolamide group
No of eyes	52	45	53
Mean age (years)	63.05 ± 9.53	60.15 ±12.08	63.88
Age range (years)	46	59	55
Sex (M:F)	26:26	18:27	24:29

Notes: All mean ± standard deviations for mean age.

Table 2 Preoperative and postoperative mean IOP (mmHg)

Time	Mean IOP change (mmHg) + DS (Range)
	Control group	Range	Acetazolamide group	Range	Dorzolamide group	Range	P Value between groups and within groups
Preoperative	12.09 ±3.19	15	12.08 ± 3.67	16	10.63 ± 2.87	11	0.035
Postoperative
16 hours	16.80 ± 8.04	37	13.11 ± 6.08	24	17.80 ± 8.22	36	0.008
24 hours	11.66 ± 5.11	26	10.61 ± 4.26	22	11.74 ± 5.03	29	0.452
48 hours	10.90 ± 3.65	18	10.01 ± 2.34	13.5	9.75 ± 2.99	18	0.138

Abbreviation: IOP, intraocular pressure.

Table 3 Mean difference IOP change (mmHg) ± SE from preoperative to 16, 24, and 48 hours postoperatively

Dependent variable	(I) medicine	(J) medicine	Mean difference (I–J)	Std Error	Sig
Base IOP	Control groups	Acetazolamide groups	0.01	0.66	1
		Dorzolamide groups	1.46	0.63	0.073
	Acetazolamide groups	Control groups	−0.01	0.66	1
		Dorzolamide groups	1.44	0.66	0.093
	Dorzolamide groups	Control groups	−1.46	0.63	0.073
		Acetazolamide groups	−1.44	0.66	0.093
IOP 16 hours	Control groups	Acetazolamide groups	3.69	1.54	0.061
		Dorzolamide groups	−0.98	1.48	0.803
	Acetazolamide groups	Control groups	−3.69	1.54	0.061
		Dorzolamide groups	−4.67	1.54	0.011
	Dorzolamide groups	Control groups	0.98	1.48	0.803
		Acetazolamide groups	4.67	1.54	0.011
IOP 24 hours	Control groups	Acetazolamide groups	1.05	0.99	0.57
		Dorzolamide groups	−0.08	0.96	1
	Acetazolamide groups	Control groups	−1.05	0.99	0.57
		Dorzolamide groups	−1.13	0.98	0.519
	Dorzolamide groups	Control groups	0.08	0.95	1
		Acetazolamide groups	1.13	0.98	0.519
IOP 48 hours	Control groups	Acetazolamide groups	0.9	0.63	0.36
		Dorzolamide groups	1.15	0.6	0.162
	Acetazolamide groups	Control groups	−0.9	0.63	0.36
		Dorzolamide groups	0.25	0.62	0.92
	Dorzolamide groups	Control groups	−1.15	0.6	0.162
		Acetazolamide groups	−0.25	0.62	0.92

Note: The mean difference is significant at the 0.05 level.

Abbreviations: IOP, intraocular pressure; SE, standard error.