Comparative studies of RNFL thickness measured by OCT with global index of visual fields in patients with ocular hypertension and early open angle glaucoma

Figures & data

Table 1 Demographic data

	1st group (54 eyes)	2nd group (42 eyes)	3rd group (73 eyes)
Age	56.7 ± 13.2	58.1 ± 11.6	60.5 ± 12.4
Sex
Males	29	22	37
Females	25	20	36
CCT mean ± SD	552.78 ± 30.18	518 ± 20.09	528 ± 32.32
IOP mean ±SD	25.11 ± 3.87	22.16 ± 2.1	26.23 ± 4.27
C/D mean ±SD	0.47 ± 0.12	0.45 ± 1.59	0.67 ± 2.34
Avg. thick mean ± SD	96.90 ± 7.52	90.12 ± 5.28	85.22 ± 5.6
MS mean ±SD	25.78 ± 4.13	26.45 ± 2.67	19.2 ± 3.1
MD mean ±SD	−1.45 ± 2.03	−1.57 ± 2.1	−6.4 ± 1.4
LV mean ±SD	−4.86 ± 2.22	−3.39 ± 1.89	−7.8 ± 2.1

Abbreviations: CCT, central corneal thickness; IOP, intraocular pressure; C/D, cup:disk ratio; Avg. thick, RNFL thickness; MS, mean sensitivity; MD, mean defect (in db); LV, loss variance; RNFL, retinal nerve fiber layer; SD, standard deviation.

Table 2 Pearson correlation of the entire group

(r) n = 169	Average RNFL thickness	Probability
Ms	0.547	P < 0.001
MD	−0.582	P < 0.001
LV	−0.527	P < 0.001

Abbreviations: MS, mean sensitivity; MD, mean defect (in db); LV, loss variance; RNFL, retinal nerve fiber layer.

Table 3 Pearson correlation of the 1st group (ocular hypertension)

(r) n = 54	Average RNFL thickness	Probability
MS	0.303	P < 0.05
MD	−0.239	P < 0.1
LV	−0.08	P > 0.1

Abbreviations: Ms, mean sensitivity; MD, mean defect (in db); LV, loss variance; RNFL, retinal nerve fiber layer.

Table 4 Pearson correlation of the 2nd group (preperimetric glaucoma)

(r) n = 42	Average RNFL thickness	Probability
MS	0.323	P < 0.05
MD	−0.209	P > 0.1
LV	−0.311	P < 0.05

Abbreviations: MS, mean sensitivity; MD, mean defect (in db); LV, loss variance; RNFL, retinal nerve fiber layer.

Table 5 Pearson correlation of subgroup A of the 2nd group

(r) n = 20	Average RNFL thickness	Probability
MS	0.477	P < 0.05
MD	−0.488	P < 0.05
LV	−0.193	P > 0.1

Abbreviations: MS, mean sensitivity; MD, mean defect (in db); LV, loss variance; RNFL, retinal nerve fiber layer.

Table 6 Pearson correlation of subgroup B of the 2nd group

(r) n = 22	Average RNFL thickness	Probability
MS	0.773	P < 0.001
MD	−0.771	P < 0.001
LV	−0.639	P < 0.001

Abbreviations: Ms, mean sensitivity; MD, mean defect (in db); LV, loss variance; RNFL, retinal nerve fiber layer.

Table 7 Pearson correlation of the 3rd group (glaucomatous)

(r) n = 73	Average RNFL thickness	Probability
MS	0.477	P < 0.001
MD	−0.487	P < 0.001
LV	−0.53	P < 0.001

Abbreviations: MS, mean sensitivity; MD, mean defect (in db); LV, loss variance; RNFL, retinal nerve fiber layer.

Figure 1 Correlation between OCT and visual fields for the right (OD) and left (OS) eye. The correlation is based on the Urlich model for the distribution of the RNFL around the optic disk.

Abbreviation: OCT, optical coherence tomography.

Table 8 Pearson correlation of group 3 (early glaucoma) for respective areas

(r) n = 73	(Tavg) (n = 14)	(Savg) (n = 26)	(Iavg) (n = 23)	(Navg) (n = 10)
MS	0.341 (P > 0.1)	0.593 (P < 0.01)	0.795 (P < 0.001)	0.828 (P < 0.01)
MD	−0.459 (P < 0.1)	−0.61 (P < 0.001)	−0.687 (P < 0.001)	−0.846 (P < 0.01)

Abbreviations: Tavg, RNFL thickness of the temporal region of the optic disk; Savg, RNFL thickness of the superior pole; Iavg, RNFL thickness of the inferior pole; Navg, RNFL thickness of the nasal region of the optic disk; RNFL, retinal nerve fiber layer.