Effects of brinzolamide vs timolol as an adjunctive medication to latanoprost on circadian intraocular pressure control in primary open-angle glaucoma Japanese patients

Figures & data

Table 1 The criteria for primary open-angle glaucoma diagnosis

Category 1

The vertical cup-to-disc ratio of the optic nerve head is 0.7 or more, or the rim width at the superior portion (11–1 hours) or the inferior portion (5–7 hours) is 0.1 or less of the disc diameter, or the difference of the vertical cup-to-disc ratio is 0.2 or more between both eyes, or a nerve fiber layer defect is found, and the hemifield-based visual field abnormality is compatible with optic disc appearance or nerve fiber layer defect

Category 2

When the visual field test result is not reliable or available, the cup-to-disc ratio of the optic nerve head is 0.9 or more, or the rim width at the superior portion (11–1 hours) or the inferior portion (5–7 hours) is 0.05 or less of the disc diameter, or the difference of the vertical cup-to-disc ratio is 0.3 or more between both eyes

Glaucoma suspect

When the cup-to-disc ratio of the optic nerve head is 0.7 or more but less than 0.9, or the rim width at the superior portion (11–1 hours) or the inferior portion (5–7 hours) is 0.1 or less but more than 0.05 of the disc diameter, or the difference of the vertical cup-to-disc ratio is 0.2 or more but less than 0.3 between both eyes, or the nerve fiber layer defect is found, and the visual field test is not reliable or available or does not show hemifield-based compatible defect, the eye is diagnosed with suspected glaucoma

Figure 1 Comparison of mean intraocular pressure levels (millimeters of mercury) for timolol and latanoprost versus brinzolamide and latanoprost across a 24-hour time period (n = 30).

Notes: *P < 0.05, **P < 0.01, ***P < 0.001, mean ± SE (paired t-test).
Abbreviations: IOP, intraocular pressure; SE, standard error.

Figure 2 Comparison of 24-hour mean IOP (averaged across all time points), diurnal mean IOP (9 AM, 12 PM, and 3 PM), and nocturnal mean IOP (9 PM, 12 AM, and 3 AM) for timolol and latanoprost versus brinzolamide and latanoprost (n = 30).

Notes: *P < 0.05, **P < 0.01, ***P < 0.001, mean ± SE (paired t-test).
Abbreviations: IOP, intraocular pressure; SE, standard error.

Figure 3 Comparison of mean maximum IOP, mean minimum IOP, and mean IOP range for eyes receiving timolol and latanoprost versus brinzolamide and latanoprost (n = 30).

Notes: *P < 0.05, mean ± SE (paired t-test).
Abbreviations: IOP, intraocular pressure; SE, standard error.

Table 2 Comparison of blood pressure and pulse rate before and after changing treatment

Blood pressure (mmHg)	Timolol + Latanoprost	Brinzolamide + Latanoprost
Systolic	128.5 ± 15.6	130.1 ± 14.7
Diastolic	78.1 ± 7.9	79.1 ± 12.6
Mean	94.5 ± 13.4	95.1 ± 11.9
Pulse rate (beat/min)	65.7 ± 5.7	72.9 ± 6.7*

* Note: P < 0.05 (paired t-test).

Table 3 Adverse events observed during the study

	Timolol + Latanoprost	Brinzolamide + Latanoprost
Ocular adverse reactions
Conjunctival hyperemia	1	0
Corneal epithelial damage	1	0
Systemic adverse reactions
Taste perversion	0	1