Daily costs of prostaglandin analogues as monotherapy or in fixed combinations with timolol, in Denmark, Finland, Germany and Sweden

Figures & data

Figure 1 Bimatoprost 0.03%: daily average of drop size by country and trend fitting.

Figure 2 Latanoprost 0.005%: daily average of drop size and trend fitting.

Figure 3 Travoprost 0.004%: daily average of drop size and trend fitting.

Figure 4 Bimatoprost 0.03% + timolol: daily average of drop size by country and trend fitting.

Figure 5 Latanoprost 0.005% + timolol: daily average of drop size and trend fitting.

Figure 6 Travoprost 0.004% + timolol: daily average of drop size and trend fitting.

Table 1 Daily drop-size (mg) by country of each drug

Drug	Drug	Country	N	Mean	(SD)	[Range]
PGA	bimatoprost 0.03%	Denmark	310	27.74	(0.943)	[23.1–31.0]
		Finland	310	28.28	(1.211)	[25.9–34.4]
		Germany	310	28.31	(0.929)	[25.9–31.2]
		Sweden	310	28.20	(0.842)	[23.1–30.8]
	latanoprost 0.005%	Denmark	310	29.99	(3.158)	[21.9–48.0]
		Finland	310	29.75	(3.373)	[20.0–48.9]
		Germany	310	29.86	(2.931)	[22.9–49.1]
		Sweden	310	29.70	(3.002)	[22.5–49.0]
	travoprost 0.004%	Denmark	310	25.87	(1.415)	[20.6–32.6]
		Finland	248	25.04	(1.756)	[17.6–28.6]
		Germany	310	26.06	(2.168)	[15.5–33.9]
		Sweden	310	24.58	(1.857)	[19.4–32.1]
PGA/timolol	bimatoprost 0.03% + timolol	Denmark	310	29.22	(1.100)	[25.3–33.2]
		Finland	310	28.49	(1.017)	[25.2–31.4]
		Germany	310	29.08	(1.308)	[22.9–35.4]
		Sweden	310	29.33	(0.995)	[25.3–32.8]
	latanoprost 0.005% + timolol	Denmark	310	30.18	(2.52)	[12.6–50.8]
		Finland	310	30.54	(2.692)	[20.6–46.1]
		Germany	310	30.42	(2.803)	[21.8–46.5]
		Sweden	310	30.22	(3.326)	[20.2–53.9]
		Denmark	310	25.79	(1.313)	[21.8–29.4]
	travoprost 0.004% + timolol	Finland	310	25.54	(1.567)	[18.9–28.9]
		Germany	310	25.85	(1.329)	[20.6–30.2]
		Sweden	310	24.57	(1.694)	[18.3–28.7]

Abbreviations:N, number of weighted drops; PGA, prostaglandin analogue; SD, standard deviation.

Table 2 Prostaglandin analogue monotherapy bottle contents and costs (euros) for Denmark

	Bimatoprost 0.03% (BP)	Latanoprost 0.005% (LP)	Travoprost 0.004% (TP)
Total fill (g)	3.22 ± 0.09	3.01 ± 0.02	2.63 ± 0.01
[Range]	[3.09–3.31]	[2.99–3.04]	[2.63–2.65]
Number of drops	104 ± 2	79 ± 2	94 ± 5
[Range]	[102–107]	[75–80]	[90–101]
No. days treatment per month	31/28	31/28	31/28
% drops remaining after monthly treatment (31/28 days)	41%/46%	21%/29%	34%/41%
Product public price	20.95	24.36	20.94
Annual cost (31 days)	247	287	247
Daily cost (31 days)	0.676	0.786	0.675
Annual cost (28 days)	273	318	273
Daily cost (28 days)	0.748	0.870	0.748

Table 3 Prostaglandin analogue monotherapy bottle contents and costs (euros) for Finland

	Bimatoprost 0.03% (BP)	Latanoprost 0.005% (LP)	Travoprost 0.004% (TP)
Total fill (g)	3.31 ± 0.08	3.00 ± 0.02	2.74 ± 0.01
[Range]	[3.249–3.43]	[2.97–3.02]	[2.73–2.74]
Number of drops	103 ± 4	79 ± 3	104 ± 11
[Range]	[98–109]	[74–82]	[93–116]
No. days treatment per month	31/28	31/28	31/28
% drops remaining after monthly treatment (31/28 days)	40%/45%	21%/29%	41%/46%
Product public price	24.97	24.97	24.11
Annual cost (31 days)	294	294	284
Daily cost (31 days)	0.805	0.805	0.778
Annual cost (28 days)	326	326	314
Daily cost (28 days)	0.892	0.892	0.861

Table 4 Prostaglandin analogue monotherapy bottle contents and costs (euros) for Germany

	Bimatoprost 0.03% (BP)	Latanoprost 0.005% (LP)	Travoprost 0.004% (TP)
Total fill (g)	3.22 ± 0.09	3.01 ± 0.02	2.68 ± 0.01
[Range]	[3.09–3.31]	[2.99–3.04]	[2.66–2.69]
Drop-count	103 ± 3	79 ± 4	92 ± 4
[Range]	[98–106]	[73–82]	[89–99]
No. days treatment per month	31/28	31/28	31/28
% drops remaining after monthly treatment (31/28 days)	40%/45%	22%/29%	33%/39%
Product public price	30.61	31.61	29.88
Annual cost (31 days)	360	372	352
Daily cost (31 days)	0.987	1.020	0.964
Annual cost (28 days)	399	412	390
Daily cost (28 days)	1.093	1.129	1.067

Table 5 Prostaglandin analogue monotherapy bottle contents and costs (euros) for Sweden

	Bimatoprost 0.03% (BP)	Latanoprost 0.005% (LP)	Travoprost 0.004% (TP)
Total fill (g)	3.22 ± 0.05	3.00 ± 0.03	2.82 ± 0.15
[Range]	[3.18–3.28]	[2.96–3.03]	[2.71–2.99]
Number of drops	103 ± 2	79 ± 2	115 ± 10
[Range]	[100–105]	[77–81]	[102–128]
No. days treatment per month	31/28	31/28	31/28
% drops remaining after monthly treatment (31/28 days)	40%/45%	21%/29%	46%/51%
Product public price	21.77	21.77	20.93
Annual cost (31 days)	256	256	246
Daily cost (31 days)	0.702	0.702	0.675
Annual cost (28 days)	284	284	273
Daily cost (28 days)	0.778	0.778	0.748

Table 6 Prostaglandin analogue/timolol fixed combination bottle contents and costs (euros) for Denmark

	Bimatoprost 0.03%/timolol BP/T	Latanoprost 0.005%/timolol LP/T	Travoprost 0.004%/timolol TP/T
Total fill (g)	3.28 ± 0.09	3.03 ± 0.05	2.87 ± 0.01
[Range]	[3.20–3.41]	[2.98–3.07]	[2.86–2.88]
Number of drops	102 ± 3	82 ± 1	104 ± 5
[Range]	[99–106]	[81–83]	[99–112]
No. days treatment per month	31/28	31/28	31/28
% drops remaining after monthly treatment (31/28 days)	39%/45%	24%/32%	41%/46%
Product public price	30.46	29.29	27.64
Annual cost (31 days)	359	345	325
Daily cost (31 days)	0.982	0.945	0.892
Annual cost (28 days)	397	382	360
Daily cost (28 days)	1.088	1.046	0.987

Table 7 Prostaglandin analogue/timolol fixed combination bottle contents and costs (euros) for Finland

	Bimatoprost 0.03%/timolol BP/T	Latanoprost 0.005%/timolol LP/T	Travoprost 0.004%/timolol TP/T
Total fill (g)	3.36 ± 0.04	3.01 ± 0.01	2.83 ± 0.01
[Range]	[3.32–3.42]	[3.00–3.03]	[2.82–2.84]
Number of drops	107 ± 2	79 ± 1	107 ± 10
[Range]	[104–110]	[78–80]	[97–124]
No. days treatment per month	31/28	31/28	31/28
% drops remaining after monthly treatment (31/28 days)	42%/47%	22%/29%	42%/47%
Product public price	30.73	30.73	29.85
Annual cost (31 days)	362	362	351
Daily cost (31 days)	0.991	0.991	0.963
Annual cost (28 days)	401	401	389
Daily cost (28 days)	1.098	1.098	1.066

Table 8 Prostaglandin analogue timolol fixed combination bottle contents and costs (euros) for Germany

	Bimatoprost 0.03%/timolol BP/T	Latanoprost 0.005%/timolol LP/T	Travoprost 0.004%/timolol TP/T
Total fill (g)	3.49 ± 0.06	3.03 ± 0.02	2.85 ± 0.02
[Range]	[3.43–3.58]	[3.01–3.05]	[2.82–2.86]
Number of drops	105 ± 3	80 ± 1	108 ± 6
[Range]	[100–108]	[78–82]	[100–116]
No. days treatment per month	31/28	31/28	31/28
% drops remaining after monthly treatment (31/28 days)	41%/47%	24%/30%	42%/48%
Product public price	33.18	34.12	31.17
Annual cost (31 days)	391	402	367
Daily cost (31 days)	1.070	1.101	1.005
Annual cost (28 days)	433	445	406
Daily cost (28 days)	1.185	1.219	1.113

Table 9 Prostaglandin analogue/timolol fixed combination bottle contents and costs (euros) for Sweden

	Bimatoprost 0.03%/timolol BP/T	Latanoprost 0.005%/timolol LP/T	Travoprost 0.004%/timolol TP/T
Total fill (g)	3.29 ± 0.04	3.03 ± 0.03	2.83 ± 0.02
[Range]	[3.22–3.34]	[2.99–3.06]	[2.81–2.85]
Number of drops	102 ± 3	80 ± 1	115 ± 9
[Range]	[98–104]	[79–81]	[102–125]
No. days treatment per month	31/28	31/28	31/28
% drops remaining after monthly treatment (31/28 days)	39%/45%	23%/30%	46%/51%
Product public price	25.50	28.96	25.50
Annual cost (31 days)	300	341	300
Daily cost (31 days)	0.823	0.934	0.823
Annual cost (28 days)	332	378	332
Daily cost (28 days)	0.911	1.034	0.911