Intraocular penetration of sequentially instilled topical moxifloxacin, gatifloxacin, and levofloxacin

Figures & data

Figure 1 Treatment schedule.

‡ 2 minutes.

Abbreviations: MFLX, moxifloxacin; GFLX, gatifloxacin; LVFX, levofloxacin.

Figure 2 High-performance liquid chromatogram of moxifloxacin, levofloxacin, and gatifloxacin.

Table 1 Mean concentration of 0.5% moxifloxacin, 0.5% levofloxacin, and 0.3% gatifloxacin in the cornea, aqueous humor, and conjunctiva

Tissue	Drug	Group 1 mean ± SD (n = 6)	Group 2 mean ± SD (n = 6)	Group 3 mean ± SD (n = 6)	Group 4 mean ± SD (n = 6)	Group 1–3 mean ± SD (n = 18)	P value* vs MFLX
Cornea	MFLX (μg/g)	7.85 ± 4.14	15.39 ± 5.88	13.46 ± 2.83	12.55 ± 3.48	12.23 ± 5.33	–
	LVFX (μg/g)	7.75 ± 2.21	7.57 ± 2.38	6.71 ± 0.83	–	7.34 ± 1.88	0.0102
	GFLX (μg/g)	4.64 ± 0.91	5.99 ± 1.39	8.32 ± 3.10	–	6.32 ± 2.47	0.0006
Aqueous humor	MFLX (μg/mL)	2.022 ± 1.250	2.876 ± 1.169	3.022 ± 0.771	2.335 ± 0.714	2.677 ± 1.094	–
	LVFX (μg/mL)	1.652 ± 0.508	1.483 ± 0.478	1.423 ± 0.225	–	1.511 ± 0.401	0.0015
	GFLX (μg/mL)	0.887 ± 0.206	1.004 ± 0.236	1.407 ± 0.596	–	1.112 ± 0.438	<0.0001
Conjunctiva	MFLX (μg/g)	2.11 ± 1.23	3.97 ± 2.03	3.49 ± 1.14	3.07 ± 1.31	3.15 ± 1.60	–
	LVFX (μg/g)	2.49 ± 1.27	1.24 ± 0.60	1.48 ± 0.38	–	1.77 ± 0.97	0.0191
	GFLX (μg/g)	1.49 ± 0.82	1.34 ± 0.58	2.61 ± 0.87	–	1.84 ± 0.94	0.0236

* Tukey’s multiple pair-wise comparison.