Treatment of retinal pigment epithelial detachment with antiangiogenic therapy

Figures & data

Table 1 Patient baseline characteristicsa

Characteristic	Pegaptanib 0.3 mg N = 7	Bevacizumab 1.25 mg N = 8
Mean age (years)	74.5	73.3
Gender
Male	4	4
Female	3	4
Treated eye
Left	4	5
Right	3	3
Phakic/pseudophakic
Phakic	5	6
Pseudophakic	2	2
Previous treatment
None	5	5
PDT with verteporfin	2	3

Note:

a Number of patients unless otherwise specified.

Abbreviation: PDT, photodynamic therapy.

Figure 1 A) Mean visual acuity (VA; Early Treatment Diabetic Retinopathy Study [ETDRS] letters) at baseline and at months 1, 3 and 6 in eyes receiving pegaptanib or bevacizumab. B) Mean foveal thickness (μm) determined by optical coherence tomography (OCT) at baseline and at months 1, 3, and 6 in eyes receiving pegaptanib or bevacizumab.

Table 2 Changes from baseline to month 6 in visual acuity and foveal thickness by treatment group, mean ± standard deviation

Outcome	Pegaptanib 0.3 mg N = 7	Bevacizumab 1.25 mg N = 8
Visual acuity, ETDRS letters
Baseline	36.1 ± 14.9	49.5 ± 11.5
Month 6	45.2 ± 19.8	56.7 ± 10.5
Change, baseline to month 6	+9.1 ± 25.3	+7.2 ± 12.3
Visual acuity, logMAR
Baseline	1.00 ± 0.31	0.72 ± 0.23
Month 6	0.80 ± 0.40	0.57 ± 0.21
Change, baseline to month 6	−0.20 ± 0.49	−0.15 ± 0.26
Foveal thickness, μm
Baseline	470.4 ± 140.8	321.1 ± 77.3
Month 6	382.2 ± 99.4	268.2 ± 35.4
Change, baseline to month 6	−88.2 ± 208.6	−52.9 ± 70.7

Abbreviations: ETDRS, Early Treatment Diabetic Retinopathy Study; logMAR, logarithm of the minimum angle of resolution.

Figure 2 A 75-year-old female patient with previously untreated advanced age-related macular degeneration in the right eye received pegaptanib every 6 weeks for 3 injections. A) Fundus photograph at baseline (left panel) and fluorescein angiography (right panel). B) Indocyanine green angiography at baseline and 6 months. C) Optical coherence tomography images and visual acuity (VA; Early Treatment Diabetic Retinopathy Study [ETDRS] letters) at baseline and months 1, 3, and 6.

Figure 3 A 76-year-old male patient having a disciform scar in the left eye and no prior treatments received 4 injections of pegaptanib. A) Fundus photograph at baseline (left panel) and fluorescein angiography (right panel). B) Optical coherence tomography images and visual acuity (VA; Early Treatment Diabetic Retinopathy Study [ETDRS] letters) at baseline and months 1, 3, and 6.

Figure 4 An 80-year-old male patient with a disciform scar in the right eye received prior photodynamic therapy with verteporfin and 3 injections of bevacizumab. A) Fluorescein angiography. B) Optical coherence tomography images and visual acuity (VA; Early Treatment Diabetic Retinopathy Study [ETDRS] letters) at baseline and months 1, 3, and 6.

Figure 5 A 61-year-old female patient with a normal right eye having received no prior treatments was administered 4 injections of bevacizumab. A) Fundus photograph at baseline (left panel) and fluorescein angiography (right panel). B) Optical coherence tomography images and visual acuity (VA; Early Treatment Diabetic Retinopathy Study [ETDRS] letters) at baseline and months 1, 3, and 6.