Serum free fatty acids levels not associated with normal tension glaucoma

Figures & data

Table 1 Demographics of the NTG and control group. Data are expressed as mean ± standard deviation

Demographics	NTG (n = 44)	Control (n = 44)	P value
Age (years)	59.9 ± 9.8	62.7 ± 14.8	0.19
Men/women	20/24	16/28	0.85
IOP right eye (mm Hg)	16.0 ± 2.3	13.6 ± 2.5	0.001
IOP left eye (mm Hg)	15.7 ± 2.5	14.2 ± 2.7	0.001
Mean deviation right eye (dB)	−6.3 ± 7.8
Mean deviation left eye (dB)	−6.2 ± 7.5
CCT right eye (μm)	526.5 ± 29.1
CCT left eye (μm)	523.9 ± 28.7
DM	4 (9.0%)	4 (9.0%)	0.92
HT	7 (15.9%)	2 (4.5%)	0.10

Notes: The IOP in Table 1 was not adjusted by calculation.

Abbreviations: NTG, normal-tension glaucoma; IOP, intraocular pressure; CCT, central corneal thickness; DM, diabetes mellitus; HT, hypertension.

Table 2 Proportional concentrations of fatty acids in serum free fatty acid in NTG patients and healthy controls (μg/mL) and the ratio of n-3 to n-6 polyunsaturated fatty acids. No significant difference was shown in any fatty acids and the ratio of n-3 to n-6 long chain polyunsaturated fatty acids

Fatty acids numerical symbol	Common name	n-x	NTG group (n = 44)		Control group (n = 44)		P value
			Mean	SD	Mean	SD
12:0	Lauric acid		3.0	3.1	4.0	4.6	0.63
14:0	Myristic acid		33.8	18.9	37.4	23.9	0.65
14:1	Myristoleic acid	n-5	0.0	0.0	0.0	0.0	1.00
16:0	Palmitic acid		783.9	254.2	764.5	259.0	0.92
16:1	Palmitoleic acid	n-7	63.7	29.0	65.7	31.8	0.67
18:0	Stearic acid		244.7	72.4	243.8	62.6	0.88
18:1	Oleic acid	n-9	656.6	305.8	617.7	216.1	0.98
18:2	Linoleic acid	n-6	923.1	231.5	900.5	177.7	0.83
18:3 (6,9,12)	Gamma-linolenic acid	n-6	10.5	6.0	10.2	5.4	0.91
18:3 (9,12,15)	Alpha-linolenic acid	n-3	29.3	15.1	27.7	12.9	0.47
20:0	Arachidic acid		8.3	2.4	8.4	1.9	0.40
20:1	Eicosenoic acid	n-11	5.5	3.3	5.8	2.7	0.15
20:2	Eicosadienoic acid	n-6	6.6	1.9	6.5	1.8	0.89
20:3 (5,8,11)	Mead acid	n-9	2.1	1.4	1.9	1.0	0.91
20:3 (8,11,14)	Dihomo-gamma-linolenic acid	n-6	31.5	11.8	33.8	12.0	0.35
20:4	Arachidonic acid	n-6	171.1	48.6	167.2	43.9	0.90
20:5	Eicosapetaenoic acid	n-3	96.4	46.7	94.6	59.1	0.55
22:0	Behenic acid		18.5	3.9	18.9	3.9	0.95
22:1	Erucic acid	n-9	1.6	0.7	1.7	0.8	0.85
22:4	Adrenic acid	n-6	4.2	1.7	4.1	1.5	0.72
22:5	Osbond acid	n-6	25.0	9.9	22.9	9.3	0.22
24:0	Lignoceric acid		16.6	3.5	16.6	3.3	0.66
22:6	Docosahexaenoic acid	n-3	162.0	54.9	151.2	56.1	0.34
24:1	Nervonic acid	n-9	36.8	8.3	37.9	9.1	0.31
n-3/n-6			0.29	0.11	0.28	0.12	0.65

Abbreviations:NTG, normal-tension glaucoma; SD, standard deviation.