The implications of pharmacogenomics in the treatment of HIV-1-infected patients of African descent

Figures & data

Table 1 Frequency of polymorphisms that affect antiretroviral drug response in Caucasians and individuals of African descent.

HLA-dependent hypersensitivity reactions
Drug(s)	Polymorphism	Prevalence
		Caucasian	African descent
Abacavir	HLA-B*5701	5.3%^Citation12	2.5%^Citation12
Adverse reactions resulting from altered pharmacokenetics
EFV, NVP	CYP2B6 516G→T	3%^Citation3	20%^Citation3
EFV, NVP	MDR1 3435C→T	49.7%^Citation22	12.6%^Citation22
EFV, NVP	CYP3 A4*1B	5.9%^Citation22	59.2%^Citation22
EFV, NVP	CYP3 A5*3	91.1%^Citation22	28.1%^Citation22
Atherogenic dyslipidemia
Protease Inhibitor	ApoC3 haplotype: −482C/−455T/Intron I G/Gly34Gly C/SstI (3238) C	45.5%^Citation49	10.8%^Citation49
Protease Inhibitor	ApoC3 haplotype: −482C/−455C/Intron I G/Gly34Gly C/SstI (3238) C	12.1%^Citation49	1.5%^Citation49
Protease Inhibitor	ApoC3 haplotype: −482C/−455T/Intron I G/Gly34Gly T/SstI (3238) C	10.5%^Citation49	6.3%^Citation49
Protease Inhibitor	ApoC3 haplotype: −482T/−455C/Intron I C/Gly34Gly C/SstI (3238) C	12.4%^Citation49	57.1%^Citation49
Protease Inhibitor	ApoC3 haplotype: −482T/−455C/Intron I C/Gly34Gly T/SstI (3238) G	8.2%^Citation49	8.2%^Citation49

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