Progress in stem cell-derived technologies for hepatocellular carcinoma

Figures & data

Figure 1 A general strategy for management of hepatocellular carcinoma based on tumor burden and the degree of liver disease. This algorithm depicts various treatment options that are used in the clinic depending upon the disease severity and the patient’s previous medical history.

Note: *Molecular and genetic prognostic markers from biopsy specimens may potentially alter existing selection criteria.
Abbreviations: AFP, alfa-fetoprotein; 3D XRT, three-dimensional conformal radiotherapy.

Table 1 Liver stem/progenitor cells

Cell type/name	Species	Reference(s)
Human progenitor cells	Human	^Citation18,Citation23,Citation26,Citation33,Citation34
Oval cells	Rat	^Citation31
	Mouse	^Citation25
	Hamster	^Citation17
Stem/progenitor cells	Rat	^Citation21
	Mouse	^Citation15,Citation25,Citation27,Citation28
	Pig	^Citation31
	Monkey	^Citation16
	Dog	^Citation20
	Human	^Citation29,Citation30,Citation33^–^Citation36
Liver-derived progenitor cells	Rat	^Citation19

Figure 2 Intra- and extrahepatic sources of stem cells from different origins that have been demonstrated to differentiate into hepatocyte-like cells.

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