Pilot study of an association between a common variant in the non-muscle myosin heavy chain 9 (MYH9) gene and type 2 diabetic nephropathy in a Taiwanese population

Figures & data

Table 1 Chromosome position, commercial assay identifier, nucleotide variation, and minor allele frequency of the selected SNP

Gene	SNP	Chromosome	Position	Commercial assay identifier	Major/minor allele	MAFa
MYH9	rs16996677	22	35057219	C_33480390_10	G/A	0.001

Notes:

a MAF in this study.

Abbreviations: MAF, minor allele frequency; SNP, single nucleotide polymorphism.

Table 2 Demographic and clinical characteristics of study subjects

Characteristic	DN (case)	T2D without DN (control)	P value
n	180	178
Age, years	58.20 ± 10.08	56.54 ± 8.99	0.1008
Gender, M/F	94/86	78/100	0.1116

Notes: Data are presented as mean ± standard deviation.

Abbreviations: DN, diabetic nephropathy; T2D, type 2 diabetes.

Table 3 Distributions of genotypes and alleles between the diabetic nephropathy (DN) cases and type 2 diabetes (T2D) without DN controls

Gene	SNP	Allele (1/2) and genotype (11/12/22)	DN	T2D without DN	Association (P value)
					Allele (1/2)	Genotype (11/12/22)	Genotype (11 + 12/22)	Genotype (11/12 + 22)	HWE
	rs16996677	G/A	353/1	356/0	0.3156	1.0000	1.0000	0.3153	0.9788
		GG/GA/AA	176/1/0	178/0/0

Abbreviations: DN, diabetic nephropathy; HWE, Hardy-Weinberg equilibrium; SNP, single nucleotide polymorphism; T2D, type 2 diabetes; MYH9, myosin, heavy chain 9, non-muscle gene.

Figure 1 The allele frequencies of the rs16996677 SNP in the MYH9 gene for the five populations of the HapMap database and the Taiwanese population collected in this study.

Abbreviations: ASW, African ancestry in southwest USA; CEU, Utah residents with northern and western European ancestry from the CEPH collection; CHB, Han Chinese in Beijing, China; JPT, Japanese in Tokyo, Japan; MYH9, non-muscle myosin heavy chain 9; YRI, Yoruba in Ibadan, Nigeria.