Update on the treatment of disseminated fusariosis: Focus on voriconazole

Figures & data

Table 1 Cases of fusariosis found by a computerized search of MEDLINE and published from January 2000 to April 2007

Article, year (Reference)	No.	Type	Pattern	Drug	Disease	Setting	Outcome with respect to the last drug
Linden et al 2000	1	not spec.	-	ABLC	-	SOT	resolved
Musa et al 2000	11	not spec.	1 cutaneous	-	Diabetes	-	-
			1 cutaneous	-	Diabetes	-	-
			1 cutaneous	-	Diabetes	-	-
			1 cutaneous	AmB-L	NHL	CTH	resolved
			1 pneumonia	-	NHL	CTH	-
			1 pneumonia	AMBD	ALL	CTH	resolved
			1 disseminated	AMBD	HM	CTH	died
			1 disseminated	AMBD	HM	CTH	died
			1 disseminated	AmB-L	HM	CTH	died
			1 disseminated	AMBD, AmB-L	HM	CTH	died
			1 disseminated	AMBD, AmB-L	HM	CTH	died
Reis et al 2000	1	solani	keratitis	Fluco,Itra,Vorico(iv, oral)	-	-	resolved
Austen et al 2001	1	dimerum	disseminated	AmB-L	ALL	CHT	died
Pereiro et al 2001	1	oxysporum	cutaneous	Itra, Fluco	-	-	improvement
Sampathkumar and Paya 2001	1	not spec.	soft tissue	ABLC	Amyl	SOT	resolved
Bodey et al 2002	35	solani,	20 disseminated	Fluco 8	Cancer	8 BMT	-
		moniliforme,	15 localized	Itra 1
		oxysporum,		AMBD, AmB-L 8
		proliferatum,		Other 18
		dimerum
Sponsel et al 2002	1	solani	endophthalmitis	AMBD + Keto, Posa	-	CL	resolved
Apostolidis et al 2003	1	not spec.	fungemia	AmB-L, Caspo	ALL	CHT	resolved
Cocuroccia et al 2003	1	solani	cutaneous	Itra	AS	SOT	improvement
Consigny et al 2003	1	not spec.	disseminated	AMBD, AmB-L, Vorico(iv, oral)	AML	CHT	resolved
Khoury and Ball 2003	1	not spec.	disseminated	AMBD	HM	BMT	resolved
Perfect et al 2003	11	not spec.	disseminated	Vorico(iv, oral)	HM	CTH+BMT	45% resp.
Rodriguez et al 2003	1	oxysporum	disseminated	AmB-L + Vorico(iv, oral)	SAA	-	resolved
Vincent et al 2003	1	solani	disseminated	ABCL, Itra, AmB-L,	AML	CTH	resolved
				Vorico(iv, oral)
Garbino et al 2004	1	not spec.	peritonitis	Vorico(iv)	Diabetes	SOT	resolved
Bigley et al 2004	1	dimerum	disseminated	AmB-L, Vorico(iv, oral)	SAA	BMT	resolved
Guimerá-MartÍn-Neda et al 2004	1	not spec.	cutaneous	AmB-L, Vorico	FES	PDN	resolved
Guzman-Cotrilli et al 2004	1	solani	disseminated	AmB-L + Vorico(iv, oral)	AML	CTH	improved
Hamaki et al 2004	1	solanii	disseminated	AMBD	NHL	BMT	died
Herbrecht et al 2004	1	proliferatum	pneumonia	Posa	-	SOT	resolved
Jensen et al 2004	4	not spec.	disseminated	AmB-L	AML	CTH	resolved
		verticillioides	disseminated	AMBD, AmB-L	CLL	CTH	resolved
		verticillioides	disseminated	AmB-L	AML	CTH	resolved
		solani	disseminated	AmB-L	NHL	CTH	died
Kivivouri et al 2004	2	solani	disseminated	AmB-L	ALL	BMT	died
		not spec.	disseminated	-	AML	BMT	died
Polizzi et al 2004	1	solani	corneal abscess	AMBD, Vorico(iv + topical, oral)	Abrasion	-	resolved
Anandi et al 2005	1	solani	cutaneous	Ketoconazole (oral)	Diabetes	-	resolved
Cudillo et al 2005	1	not spec.	disseminated	AmB-L, Vorico (oral), AmB-L	ALL	CTH	died
Durand et al 2005	1	moniliforme	endophthalmitis	AMBD(topical), Vorico(oral)	Catarct	-	resolved
Lodato et al 2005	1	solani	liver abscesses	ABLC	CD	SOT	resolved
Lin et al 2005	3	solani	keratitis	Netamycin(ed)	-	-	resolved
		solani	keratitis	Netamycin(ed) + Keto(oral)	-	-	resolved
		solani	keratitis	Netamycin(ed) + Fluco(oral)			resolved
Giaconi et al 2006	1	oxysporum	keratitis	Vorico(topical)	-	-	not resolve
Gorman et al 2006^8	1	oxysporum	pneumonia	Vorico(oral)	-	-	resolved
Hsu et al 2006	1	not spec.	cutaneous	Vorico(oral)	NHL	-	resolved
Madariaga and Kohl 2006	1	not spec.	disseminated	Vorico(iv)	Emph	PDN	-
Sagnelli et al 2006	1	verticillioides	disseminated	Vorico(iv, oral)	ST	CTH	resolved
Selleslag 2006	1	solani	disseminated	AmB-L	ALL	CTH	resolved
Stanzani et al 2006	1	solani	disseminated	AmB-L + Vorico(iv, oral)	AML	BMT	resolved
Bunya et al 2007	3	not spec.	keratitis	Vorico(topical)	-	-	resolved
		not spec.	keratitis	Vorico(orlal + topical)	-	-	resolved
		not spec.	keratitis	Vorico(oral + topical)	-	-	not resolved
Tu et al 2007	3	not spec.	endolphalmitis	AMBD(topical), Vorico(iv), Posa	-	CL	resolved
		not spec.	keratitis	AMBD(topical), Vorico(topical + oral), Posa	-	-	resolved
		not spec.	endolphalmitis	Vorico(topical + iv, oral), Posa	-	CL	resolved

Abbreviations: ABLC, amphotericin B lipid complex; AmB-L, liposomal amphotericin B; AMBD, amphotericin B deoxycholate; ALL, acute lymphoblastic leukemia; AML, acute myeloid leukemia; Amyl, amyloidosis; AS, Alport syndrome; BMT, allogeneic bone marrow transplantation; Caspo, caspofungin; CD, Caroli’s disease; CHT, chemotherapy; CL, contact lens; ed, eye drops; Emph, emphysema; FES, Fisher-Evans syndrome; Fluco, fluconazole; HD, Hodgkin disease; HM, hematological malignancies; Itra, itraconazole; Keto, ketoconazole; PDN, steroids; Posa, posaconazole; SOT, solid organ transplant; ST, solid tumor; Vorico, voriconazole.

Figure 1 Patient with disseminated fusariosis and skin involvement. The lesions are seen most commonly on extremities and appear as widespread, violaceous (A) or erythematous indurated elements (B). With the resolution of the infection the skin lesions become darker (C) and the lesions disappear (D).

Figure 2 Biopsy of nodular skin lesion at the diagnosis (A) and after treatment (B).

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