New treatment options in allergic rhinitis: patient considerations and the role of ciclesonide

Figures & data

Table 1 Ciclesonide clinical trials in allergic rhinitis

Author (year)	Disease	Method	Patients	Duration	Outcomes	Results
Ratner (2006b)	SAR	DBPCR	327	28 days	Efficacy, safety, tolerabily	“Intranasal ciclesonide was superior to placebo in relieving nasal symptoms in[..]confirm the dose range-finding study and support the efficacy of ciclesonide in AR”
Nave (2006)	SAR	DBPCR	48	14 days	Efficacy, safety, tolerabiliy	“The low systemic exposure and favorable safety profile support the continued clinical development”
Ratner (2006a)	SAR	DBPCR	145	14 days	Efficacy, safety	“200 μg appears to be the optimal dose studied for reducing the symptom of SAR wile mantaining an acceptable safety profile”
Meltzer (2007)	PAR	DBPCR	471	42 days	Efficacy, safety	“Significant reductions in nasal symptoms and appociable improvements in health quality of life. Ciclesonide was well tolerated”
Schmidt (1999)	AR	DBPCR	24	14 days	Efficacy, safety, tolerabily	“The treatment with ciclesonide is effective, without producing local or systemic side effects”
ALTANA Pharma (2006)	SAR PAR	4DBPCR	1524 in 3 trials	3 trials: 2–6 weeks 1 trial:1 year	Efficacy, safety, tolerabily	“The results showed that patients treated with 200 μg once daily exhibited statically significantly greater decreases in total nasal symptom scores than placebo treated patients. Measures of efficacy were also generally supportive”

Abbreviations: AR, allergic rhinitis; DBPCR, double blind, placebo-controlled, randomized trial; PAR, perennial allergic rhinitis; SAR, seasonal allergic rhinitis.

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