The treatment of chronic hepatitis B: Focus on adefovir-like antivirals

Figures & data

Figure 1 Efficacy of HBV drugs (48–52 week data). Lai CL, et al. Hepatology 2005; 42:748A (AASLD abstract LB01); Lau G, et al. NEJM 2005; 352:2882–2695; Chang T-T, et al. NEJM 2006; 354:1000–1010; Marcellin P, et al. NEJM 2003;348:808–816. #Heathcote J et al. AASLD 2007, Marcellin P, et al. AASLD 2007.

Notes: ^*Undetectable <300 copies/mL, ^#Undetectable <400 copies/mL, ^§Undetectable <1000 copies/mL.

Table 1 Resistance defined by 1 log viral load increase over nadir after one and two years within the GLOBE trial

Rate of resistance	Lamivudine		Telbivudine
	HBeAg-positive	HBeAg-negative	HBeAg-positive	HBeAg-negative
Year 1	8.2	3.0	8.5	2.1
Year 2	35.0	21,6	21.6	8.6

Adapted from Han et al (2007).

Table 2 Viral load reduction on alamifovir

Parameter	N	Placebo	2.5 mg/d	5 mg/d		10 mg/d		20 mg/d
			2.5 mg QD	2.5 mg BID	5 mg QD	5 mg BID	10 mg QD	10 mg BID	20 mg QD
Log-change on day 29	Mean drop	0,064	1,52	2,02	1,96	1,98	2,49	2,53	2,50

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