Figures & data
Figure 1 The epidermal growth factor receptor pathway. Signaling through the epidermal growth factor receptor initiates a cascade intracellular cell signaling events which result in proliferation, angiogenesis and cell survival.
Abbreviations: BAD, pro-apoptotic protein of the bcl-2 family; ERK: extracellular signal regulated kinase; GSK: glycogen synthase kinase; Mabs, monoclonal antibodies; MEK: mitogen-activated protein kinase; mTOR, mammalian target of rapamycin; NF-kB, nuclear factor-kappa B; PDK: 3-phosphoinositide dependent kinase; PI3K, phopsphatidylinositol-3-kinase; PIP3: phosphatiyidylinositol (3,4,5)-triphosphate; PTEN, phosphatase and tensin homolog detected on chromosome 10; Ras/Raf: Serine/threonine kinase family;TKIs, tyrosine kinase inhibitors.
Table 1 Therapeutic approaches to targeting the epidermal growth factor receptor
Figure 2 Study schema for the AVITA randomized Phase III study.
Table 2 Toxicities associated with the combination of erlotinib and gemcitabine in the NCIC Phase III study