Long-term management of gastroesophageal reflux disease with pantoprazole

Figures & data

Table 1 Randomized clinical trials comparing the efficacy of maintenance therapy with pantoprazole versus other acid suppressing agents in patients with healed erosive esophagitisa

Reference	Treatment (No of patients)	Endoscopic remission rate at study end (% patients)		Symptomatic control at study end (% patients)
Comparisons with other proton pump inhibitors
Goh et al 2007 (double-blind, 6-month trial)	Pantoprazole 20 mg once daily (636)		84b
	Esomeprazole 20 mg once daily (667)		85b
Labenz et al 2005 (double-blind, 6-month trial)	Pantoprazole 20 mg once daily (1389)	77**		88.5*
	Esomeprazole 20 mg once daily (1377)	88		92
Lauritsen et al 2000 (double-blind, 12-month trial)	Pantoprazole 20 mg once daily (211)	77		83
	Pantoprazole 40 mg once daily (218)	83		87
	Omeprazole 20 mg once daily (210)	81		86
Comparisons with ranitidine
Adamek et al 2001 (double-blind, 12-month trial)	Pantoprazole 20 mg once daily(199)	66**		73%*
	Ranitidine 150 mg once daily (104)	34		65%
Metz et al 2003 (double-blind, 12-month trial)	Pantoprazole 10 mg once daily (89)	40
	Pantoprazole 20 mg once daily (93)	68
	Pantoprazole 40 mg once daily (94)	82
	Ranitidine 150 mg twice daily (95)	33†
Richter et al 2004 (double-blind, 12-month trial)	Pantoprazole 10 mg once daily (88)	46
	Pantoprazole 20 mg once daily (88)	55*
	Pantoprazole 40 mg once daily (85)	78*
	Ranitidine 150 mg twice daily (88)	21

a Note: Results of intention-to-treat analyses;

b Endoscopic plus symptomatic control;

* p < 0.001;

** p ≤ 0.0001 versus esomeprazole or ranitidine;

† p < 0.001 versus all doses of pantoprazole.

Figure 1 On-demand therapy with pantoprazole leads to lower heartburn intensity than with esomeprazole in patients with mild GERD.

Note: *Statistically significant difference;The intensity of symptoms was rated on a 4 point-scale (0: none, 1: mild, 2: moderate, 3: severe).
Abbreviations: ITT, intention to treat population; PP, per protocol population.

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