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Review

Optimizing prophylactic treatment of migraine: Subtypes and patient matching

Pages 1061-1078 | Published online: 10 Oct 2008

Figures & data

Figure 1 Potential long-term course of migraine headaches.

Figure 1 Potential long-term course of migraine headaches.

Figure 2 A classification of migraine headaches based on triggering factors.

Figure 2 A classification of migraine headaches based on triggering factors.

Figure 3 Relief of migraine attack in 235 patients included in a comparative study of ketoprofen and zolmitriptan using a cross-over design (CitationDib et al 2002). Data are given as the percentage of the total number of attacks that were reduced in severity to mild or absent at two hours. Treatment groups are placebo (P), ketoprofen 75 mg (K75), ketoprofen 150 mg (K) and zolmitriptan 2.5 mg (Z). The asterisk indicates a significant difference (p < 0.0001; GEE model) between the bracketed groups.

Figure 3 Relief of migraine attack in 235 patients included in a comparative study of ketoprofen and zolmitriptan using a cross-over design (CitationDib et al 2002). Data are given as the percentage of the total number of attacks that were reduced in severity to mild or absent at two hours. Treatment groups are placebo (P), ketoprofen 75 mg (K75), ketoprofen 150 mg (K) and zolmitriptan 2.5 mg (Z). The asterisk indicates a significant difference (p < 0.0001; GEE model) between the bracketed groups.

Figure 4 Treatment hierarchy for the acute treatment of migraine with triptans.

Figure 4 Treatment hierarchy for the acute treatment of migraine with triptans.

Table 1 Prophylactic treatments for migraine

Figure 5 Efficacy of topiramate in the prophylaxis of migraine. Three different doses of topiramate (TPM; 50 mg/day, 100 mg/day, and 200 mg/day) are compared with placebo (Pbo). Data represent the change in monthly migraine frequency compared to a pre-treatment baseline period. The asterisks indicate a statistically significant difference from placebo (*p < 0.01; **p < 001). Data are taken from CitationBrandes and colleagues (2004) (grey columns) and CitationSilberstein and colleagues (2004) (black columns).

Figure 5 Efficacy of topiramate in the prophylaxis of migraine. Three different doses of topiramate (TPM; 50 mg/day, 100 mg/day, and 200 mg/day) are compared with placebo (Pbo). Data represent the change in monthly migraine frequency compared to a pre-treatment baseline period. The asterisks indicate a statistically significant difference from placebo (*p < 0.01; **p < 001). Data are taken from CitationBrandes and colleagues (2004) (grey columns) and CitationSilberstein and colleagues (2004) (black columns).