Managing pediatric hepatitis C: current and emerging treatment options

Figures & data

Table 1 Terminology for virologic response commonly used in predicting the outcome of hepatitis C virus (HCV) treatment¹⁰

Terminology	Definition
Sustained virologic response (SVR)	Undetectable serum HCV-RNA determined with the most sensitive polymerase chain reaction (PCR) technique 24 weeks after the end of treatment (ETR)
Rapid virologic response (RVR)	Undetectable serum HCV RNA (<50 IU/ml) by treatment week 4
Early virologic response (EVR)	≥ 2 log10 IU/mL (100-fold) decline in serum HCV RNA from pretreatment baseline or undetectable serum HCV RNA by treatment week 12
Partial virologic response	≥ 2 log10 IU/mL (100-fold) decline in serum HCV RNA from pretreatment baseline at treatment week 12 but serum HCV RNA still detectable at treatment week 24
Null response	< 2 log10 IU/mL (100-fold) decline in serum lf HCV RNA from pretreatment baseline 12 weeks after treatment was initiated
Virologic breakthrough	Reappearance of serum HCV RNA during treatment after initially becoming undetectable HCV RNA
Relapse	Reappearance of serum HCV RNA after the treatment were discontinued in a patient who achieved and maintained undetectable HCV RNA throughout the duration of treatment

ShiffmanMLChronic hepatitis C: treatment of pegylated interferon/ribavirin nonrespondersCurr Gastroenterol Rep20068465216510034

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