Parenteral clevidipine for the acute control of blood pressure in the critically ill patient: a review

Figures & data

Figure 1 Structure of clevidipine.

Table 1 Pharmacology of clevidipine

Generalities
Class	Dihydropyridine
Pharmacokinetics
Metabolism	Ester hydrolysis in blood
Metabolite	Inactive carboxylic metabolite H152/81
Plasma protein binding	>99.5%
Volume of distribution	0.51–0.58 L/kg
Half-life	Phase 1 =1.6
	Phase 2 =15.5
Blood clearance	0.105 L/min/kg

Table 2 Frequency of adverse effects

Adverse effect	Frequency
Flushing	40%
Fever	18.9%
Atrial fibrillation	13.2%
Acute renal failure	9.4%
Nausea	5.7%