Arterial Stiffness and Pharmacological Interventions – The TRanscend Arterial stiffNess Substudy (TRANS study)

Figures & data

Figure 1 Change in arterial distensibility after antihypertensive treatment in three arterial sites: abdominal aorta, carotid artery and brachial artery. Significant site effect was observed:

Table 1 Effects of antihypertensive drugs on pulse wave velocity

	Short term treatment <28 days		Long term treatment ≥28 days
	Aorta	Arm/Leg	Aorta	Arm/Leg
Vasodilators	≡
Beta-blockers	↘/≡		↘/≡	↘/≡
Diuretics			≡/↘	≡
Calcium antagonists	≡		↘	↘/≡
ACE inhibitors	↘	↘	↘	↘
ARBs	↘	↘	≡/↘

Abbreviations: ACE, angiotensin converting enzymes; ARB, angiotensin II receptor blocker

Table 2 TRANS investigating centers distribution and number of patients enrolled

Countries	Number of centers	Number of patients enrolled
Belgium	2	18
China	5	100
Czech Republic	5	75
Greecev	3	16
Ireland	1	2
Malaysia	1	11
Netherlands	1	2
Portugal	1	3
South Africa	2	12
Sweden	1	5
Ukraine	4	52
Total	26	296

Table 3 Baseline clinical characteristics of the TRANS study population

N = 279	Mean ± SD	Range
Age (years)	67 ± 7	43–88
Gender		M: 160 (57.3%)
		F: 119 (42.6%)
Height (cm)	166 ± 9	140–191
Weight (kg)	77 ± 13	41–123
Systolic BP (mmHg)	139 ± 17	95–200
Diastolic BP (mmHg)	80 ± 10	51–112
Heart rate (beat/min)	66 ± 11	45–111
Carotid-femoral PWV (m/s)	10.0 ± 2.6	4.7–21.4
Carotid-radial PWV (m/s)	9.1 ± 1.4	5.3–13.6

Abbreviations: BP, blood pressure; PWV, pulse wave velocity.

Table 4 Diagnosis and previous diseases of the TRANS study population

	N	%
Coronary artery disease	190	68
Peripheral arterial disease	18	6
Previous stroke	87	31
TIA (>7 days and <1 year)	11	4
High-risk diabetes	35	13

Abbreviations: TIA, transient ischemic attack.

Table 5 Biochemical results of the TRANS study population

	N	Mean	SD
Creatinine (mmol/L)	280	91.8	23.8
Potassium (mmol/L)	280	4.4	0.4
Sodium (mmol/L)	280	140.7	4.1
Urea (mmol/L)	279	6.8	3.3
Plasma glucose (mmol/L)	280	6.5	2.4
Cholesterol (mmol/L)	280	5.2	1.2
Triglycerides (mmol/L)	280	1.9	1.4
HDL (mmol/L)	279	1.3	0.3
LDL (mmol/L)	277	3.1	1.0

Abbreviations: HDL, high density lipoprotein; LDL, low density lipoprotein.

TopouchianJAsmarRSayeghFChanges in arterial structure and function under trandolapril-verapamil combination in hypertensionStroke19993010566410229744

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