Adult nontwin sib concordance rates for type 2 diabetes, hypertension and metabolic syndrome among Asian Indians: The Indian Atherosclerosis Research Study

Figures & data

Table 1 Details of IARS families

Descriptives	Number	Percent	Mean ± SD
Total number of families	508
Total number of individuals	2313
Average number per family	4.35
Number of sibships	527
Total number of males	1353	58.5
Males with CAD	630	46.6
Unaffected males	723	53.4
Number of females	960	41.5
Females with CAD	142	14.8
Unaffected females	818	85.2
Mean age at recruitment (in yrs) – affected males			55.5 ± 9.3
Mean age at recruitment (in yrs) – affected females			57.9 ± 9.3
Mean age at recruitment (in yrs) – unaffected males			37.2 ± 14
Mean age at recruitment (in yrs) – unaffected females			43.2 ± 13.7
Mean age at onset of CAD (in yrs) – males			50.3 ± 8.4
Mean age at onset of CAD (in yrs) – females			53 ± 8.8
CAD subjects with diabetes (N)	347	45
Unaffected subjects with diabetes (N)	164	10.6
CAD subjects with hypertension (N)	419	54.4
Unaffected subjects with hypertension (N)	267	17.3
BMI (kg/m^2) – males			25.5 ± 4.8
BMI (kg/m^2) – females			25.4 ± 5.2

Table 2 Concordance rates for diabetes (T2DM), hypertension (HTN), and metabolic syndrome (MS) among the sib-pairs and spouse-pairs

Descriptive	T2DM	HTN	MS
Sib-pairs (N)	1250	1250	1250
Sib-pairs both with the trait (N)	136	174	287
Sib concordance rate for the trait	11.00%	14.00%	23.00%
Corresponding spouse-pairs (N)	463	463	463
Spouse-pairs both with the trait (N)	13	29	130
Sib-spouse concordance for the trait	2.80%	6.26%	28.10%
Chi square values for difference in concordance rates between sib-pairs and spouse-pairs	26.71	18.23	4.531
‘p’ value	<0.0001	<0.0001	0.0333

Note: Metabolic syndrome diagnosed as per NCEP ATPIII Criteria (2001).