Figures & data
Figure 1 Rosuvastatin increases RBC-NOS activity. RBC-NOS activity was measured by the level of eNOS protein phosphorylation and by accumulated plasma nitrite depending on rosuvastatin. (A) Phosphorylation of eNOS at Ser1177 was used to examine the phosphorylation dependent activation status of the eNOS. RBCs incubated with rosuvastatin showed a significant rise of eNOS phosphorylated at Ser1177 as compared with control. (B) Accumulated nitrite was determined in blood samples after incubation under control conditions with and without rosuvastatin. Changes in plasma nitrite reflect the sum of the release (due to NOS-dependent NO-formation) and the reuptake of nitrite by RBC.
Figure 2 Effect of rosuvastatin on RBC-NOS activity and RBC deformability. Parallel to the RBC-NOS activity (detected as accumulated plasma nitrite concentration) flow rate of RBC through a microfilter (as a measure of RBC deformability) were determined after incubation of whole blood with (black squares) and without rosuvastatin (white squares).
