Figures & data
Figure 1 The role of the renin angiotensin aldosterone system in vascular disease. Angiotensin II (AII) is an important mediator of vascular damage that promotes the development of atherothrombosis and the complications of atherosclerosis.
Figure 2 Study design and outcomes of ONTARGET and TRANSCEND studies.
Figure 3 Relative risk for primary outcome (cardiovascular death, MI, stroke and hospitalization for heart failure) and secondary HOPE study outcome (cardiovascular death, MI or stroke). The confidence interval is well within the predefined boundary for non-inferiority of telmisartan compared with ramipril.
Figure 4 TRANSCEND study comparing telmisartan 80 mg daily with placebo in high risk patients. Kaplan-Meier Curves for the secondary outcome of cardiovascular death, MI or stroke (HOPE study outcome). After statistical correction for multiple comparisons and overlap with the primary endpoint, the difference was not statistically significant (p = 0.68).
Figure 5 Relative risks for secondary HOPE study endpoint of cardiovascular death, MI and stroke in the TRANSCEND study.
