Effect of losartan on Doppler sonography indices in kidney transplant patients: A randomized clinical trial

Figures & data

Table 1 Baseline characteristics of patients

Characteristic	Losartan group (n = 25)	Control group (n = 25)	P value
Age (years)	36 ± 12	42 ± 14	0.1
Male sex: no (%)	12 (48%)	18 (72%)	0.083
Male donor sex: no (%)	20 (80%)	23 (92%)	0.29
BMI	24.7 ± 4.7	25.6 ± 3.9	0.3
Time since transplant (months)	47 ± 36	44 ± 24	0.6
Episode of AR before study: no (%)	1 (4%)	3 (12%)	0.6
Diabetes: no (%)	3 (12%)	1 (4%)	0.3
Hypertension: no(%)	13 (52%)	12 (48%)	0.7
MAP (mmHg)	99 ± 10.5	97 ± 10	0.33
Serum creatinine mg/dL	1.2 ± 0.3	1.2 ± 0.3	0.9
Serum potassium meq/L	4.3 ± 0.4	4.5 ± 0.4	0.4
Cyclosporine level (ng/mL)	187 ± 67	204 ± 75	0.9

Abbreviations: AR, acute rejection; BMI, body mass index; MAP, mean arterial pressure.

Table 2 Doppler sonography indices in the losartan and control groups

	Intrarenal artery			Main renal artery
	Losartan group (n = 25)a	Control group (n = 25)	P value	Losartan group (n = 25)a	Control group (n = 25)	P value
Baseline
RI	0.7 ± 0.06	0.69 ± 0.08	0.8	0.72 ± 0.07	0.72 ± 0.07	0.9
PI	1.2 ± 0.3	1.3 ± 0.4	0.3	1.4 ± 0.3	1.4 ± 0.32	0.8
6 months
RI	0.72 ± 0.06	0.7 ± 0.06	0.2	0.75 ± 0.04	0.73 ± 0.07	0.19
PI	1.4 ± 0.3	1.4 ± 0.3	0.7	1.57 ± 0.28	1.54 ± 0.3	0.7
12 months
RI	0.71 ± 0.06	0.69 ± 0.07	0.4	0.74 ± 0.07	0.72 ± 0.07	0.3
PI	1.3 ± 0.25	1.29 ± 0.28	0.8	1.5 ± 0.3	1.4 ± 0.34	0.3

Abbreviations: RI, resistive index; PI, pulsatility index.

Note: ^aOne patient in the losartan group was lost to follow-up.