Lipoprotein-Associated Phospholipase A₂, Vascular Inflammation and Cardiovascular Risk Prediction

Figures & data

Table 1 Studies and trials demonstrating significant independent association between Lp-PLA₂ levels and cardiovascular endpoints, expressed either as HR (highest compared with lowest tertile, quartile, or quintile) or RR per 1 SD

Author	Population	Endpoints	Risk
			HR
Ballantyne	ARIC:Healthy subjects	Coronary events	2.08 (LDL<130)
Ballantyne	ARIC:Healthy subjects	Stroke	1.97
Khusiyenova	Southern Germans:CAD	Presence of CAD	1.84
Oei	Rotterdam:Elderly	Coronary events/stroke	1.96/1.95
			RR per 1 SD
Packard	WOSCOPS:Hypercholesterolemia	Cardiac events	1.18
Brilakis	Mayo Clinic study:CAD	Cardiac events	1.27
Iribarren	CARDIA:Youngadults	Coronary calcification	1.25
Koenig	MONICA:Healthy men	Coronary events	1.21

Abbreviations: ARIC, Atherosclerosis Risk in Communities; CAD, coronary artery disease; CARDIA, Coronary Artery Risk Development in Young Adults; HR, hazard ratio; LDL, low-density lipoprotein; MONICA, Monitoring Trends and Determinants in Cardiovascular Diseases; RR, risk ratio; SD, standard deviation; WOSCOPS, West of Scotland Coronary Prevention Study.