Effect of ramipril on renal function in patients with intermittent claudication

Figures & data

Figure 1 Boxplots of change in serum creatinine in response to initiation of ramipril. Patients are commenced on ramipril 2.5 mg for 1 week, increased to 5 mg for 3 weeks, and then maintained on 10 mg. Compared with baseline, 1 week p = 0.015, 5 weeks p ≤ 0.001, 12 weeks p = 0.003, Wilcoxon signed ranks).

Figure 2 Boxplots of change in glomerular filtration rate in response to initiation of ramipril. Patients are commenced on ramipril 2.5 mg for 1 week, increased to 5 mg for 3 weeks, and then maintained on 10 mg. Compared with baseline, 1 week p = 0.009, 5 weeks p ≤ 0.001, 12 weeks p = 0.015, Wilcoxon signed ranks).

Table 1 Demographic details of patients commenced on ramipril

Variable
Number of subjects	54
Median age [IQR]	67.5 [59–76]
Sex (M:F ratio)	3.5:1
Ischemic heart disease
Myocardial infarction/angina	8
Coronary artery bypass graft	1
Cerebrovascular disease
Cerebrovascular accident	1
Transient ischemic attack	0
Diabetes mellitus	8
Hypertension	27
Medication
Antiplatelet agent	54
Statin	53
Antihypertensive	25
Insulin	2
Oral hypoglycemic	1
Mean ABPI (range)	0.72 (0.40–0.85)

Abbreviations: ABPI, ankle brachial pressure index; IQR, interquartile range.