Targeting mulitple dyslipidemias with fixed combinations – focus on extended release niacin and simvastatin

Figures & data

Figure 1 Structural formula of simvastatin.

Figure 2 Structural formula of niacin.

Table 1 Recommended dosing regimen of niacin ER

Week(s)	Daily dose of niacin ER
1 to 4	500 mg
5 to 8	1000 mg
At least 4 weeks	1500 mg
At least 4 weeks	2000 mg

Notes: The dose of niacin extended-release should not be increased by more than 500 mg daily every 4 weeks.

The efficacy and safety of doses of simvastatin and niacin ER combination greater than 2000/40 mg daily have not been studied and are therefore not recommended. Combination of simvastatin and niacin EF (Simcor^® tablets) should be taken whole and should not be broken, crushed, or chewed before swallowing.