Cardiometabolic risk in psoriasis: differential effects of biologic agents

Figures & data

Table 1 Factors associated with metabolic abnormalities in systemic inflammatory diseases

Disease	Risk factor	Preventive strategy
SLE	Steroids	Minimize prolonged steroid use (Bultink et al 2008)
SLE	Active disease	Adequate control of disease activity (Sidiropoulos et al 2008)
SLE	Sedentary life-style	Exercise (Negron et al 2008)
RA	Active disease	Adequate control of disease activity (Dessein and Joffe 2006)
RA	Obesity	Normal body mass (Dessein and Joffe 2006)
AS	Active disease	Adequate control of disease activity (Sidiropoulos et al 2008)

Abbreviation: AS, ankylosing spondylitis; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus.

Table 2 Preventive strategies for traditional and non-traditional cardiovascular risk factors in patients with psoriasis

Risk factor	Preventive strategy
Smoking	Counseling, nicotine patches/gum, bupropion
Obesity	Counseling, diet, exercise
Hypertension	Monitoring, diet, exercise, minimize corticosteroids and NSAIDS; prompt use of antihypertensives
Hyperlipidemia	Monitoring, counseling, diet, exercise, limit systemic corticosteroids.
Insulin resistance	Anti-inflammatories/biologicals
Hyperhomocystenemia	Folic acid supplementation with methotrexate use
Family history of CVD	Counseling, monitoring risk factors
Inflammation	Anti-inflammatories, biologicalsa.
Additional prethrombotic risk	Low dose aspirin/consider anticoagulation.

a Hypothetical. Requires confirmation with controlled studies.