Figures & data
Figure 1 Potential mechanisms responsible for the hypocholesterolemic effects associated with the consumption of soluble fibers. Copyright © 2007. Adapted with permission from Rideout TC, Yuan Z, Bakovic M, et al. 2007. Guar gum consumption increases hepatic nuclear SREBP2 and LDL receptor expression in pigs fed an atherogenic diet. J Nutr, 137:568–72.
Abbreviations: ABCG5/G8, ATP-binding cassette transporter G5 and G8; C, cholesterol; CE, cholesteryl ester; CYP7A, cholesterol 7a-hydroxylase; GG, guar gum; LDLr, low-density lipoprotein receptor; NPC1L1, Niemann-Pick-C-1 like 1; SCFA, short-chain fatty acids; SREBP2, sterol regulatory element binding protein 2.
Figure 2 Major pathways involved in regulating the enterohepatic circulation of cholesterol. Copyright © 2007. Adapted with permission from Rideout TC, Yuan Z, Bakovic M, et al. 2007. Guar gum consumption increases hepatic nuclear SREBP2 and LDL receptor expression in pigs fed an atherogenic diet. J Nutr, 137:568–72.
Abbreviations: ABCG5, ATP-binding cassette transporter G5; ABCG8, ATP-binding cassette transporter G5; ACAT, acyl-coenzyme A:cholesterol acyltransferase; ASBT, apical sodium-dependent bile acid transporter; C, cholesterol; CE, cholesteryl ester; CEL, carboxyl ester lipase; CYP7A, cholesterol 7α-hydroxylase; HDL, high-density lipoprotein; ABCA1, ATP-binding cassette transporter A1; HMG-CoAr, 3-hydroxy-3-methylglutaryl-CoA reductase; LDLr, low-density lipoprotein receptor; NPC1L1, Niemann-Pick-C-1 like 1; SR-B1, scavenger receptor class B, type 1; VLDL, very-low density lipoprotein.
