Long-acting nifedipine in the management of the hypertensive patient

Figures & data

Table 1 Incidence of adverse events reported in clinical trials

Adverse event	White et al 1998 (mean 64 mg/day)	Toal et al 2004 (60 mg/day)	Pfizer 2003 180 mg/day	Fogari et al 2005 60 mg/day	Weir et al 1996 30, 60, or 90 mg/day	Testa et al 1998 30 mg/day
Overall incidence	74%	24%			61%
Peripheral edema	22%		10%–30%	13.8%	12%	24.2%
Constipation	8%		3.3%
Arthralgia	6%		<3%
Back pain	1%		<1%
Headache		21%	15.8%	5.2%	12%	12.4%
Dizziness		3%	4.1%	1.7%	1%
Nausea		3%	3.3%	1.7%
Vomiting		7%	<1%
Increased alk phos			5.4%
Fatigue			5.9%	–	2%
Polyuria			<3%	1.7%
Rash erythematosus			<3%	1.7%
Flushing			<3%	5.2%		8.4%
Palpitation			<3%	3.4%
Pruritus			<3%	1.7%

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ToalCB2004Formulation dependent pharmacokinetics - does the dosage form matter for nifedipine?J Cardiovasc Pharmacol4482615175561

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TestaMTurnerRRSimonsonDC1998Quality of life and calcium channel blockade with nifedipine GITS versus amlodipine in hypertensive patients in SpainJ Hypertens161839479869019

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