Effects of allopurinol and vitamin E on renal function in patients with cardiac coronary artery bypass grafts

Figures & data

Table 1 Baseline clinical and demographic characteristics of patients in the control and treatment groups

Variable	Treatment group	Control group	p value
Age	65 ± 9.5 years	61 ± 7.90 years	0.103
Sex (M/F)	17/13	14/16	0.4
BMI	24.4 ± 3.22	24.1 ± 2.53	0.77
DM (no.)	11	18	0.71
HTN (no.)	14	18	0.59
History of MI (no.)	17	11	0.108
Smoking (no.)	11	4	0.016
Duration of operation (h)	3.6 ± 0.56	3.2 ± 0.83	0.169
Duration of aortic clamp (min)	32.5 ± 13.33	24.3 ± 9.76	0.185
Pump on (no.)	25	18	0.31
Preoperation EF	44.7 ± 12.29	49.4 ± 12.6	0.354
Preoperation serum Cr (mg/dL)	1.3 ± 0.45	1.3 ± 0.53	0.918
Preoperation serum potassium (meq/L)	4.6 ± 0.48	4.2 ± 0.66	0.019
Preoperation CCr (mL/min)	48 ± 10	50 ± 10.3	0.412
Urine volume (mL)	1689.1 ± 921.20	1530.0 ± 554.43	0.518

Notes: ^aNormal distribution of continuous variables was proven by Kolmogorov–smirnov;

^b By a Bonferroni correction, a p value < 0.00333 was considered significant.

Abbreviations: BMI, body mass index; DM, diabetes mellitus; HTN, hypertension; MI, myocardial infarction; EF, ejection fraction; Cr, creatinine; CCr, creatinine clearance; h, hour; min, minute.

Table 2 Clinical and paraclinical state of patients during and after surgery in the treatment and control groups

Variable	Treatment group	Control group	P value
Postoperation serum potassium (meq/L)	4.4 ± 0.30	4.3 ± 0.36	0.784
Postoperation serum creatinine (mg/dL)	1.2 ± 0.33	1.2 ± 0.40	0.435
Postoperation CCr (mL/min)	52.5 ± 12.84	52.3 ± 12.89	0.952
Postoperation ARF (no.)	5	4	0.5
Postoperation EF	44 ± 10.9	45 ± 10.4	0.74
Received dopamine infusion (no.)	8	5	0.65
Hypotension (systolic BP ≤90 mm Hg) (no.)	1	6	0.034
Arrhythmia (no.)	12	18	0.56
ICU stay (day)	2.6 ± 0.75	3.9 ± 1.54	0.000

Notes: ^aNormal distribution of continuous variables was proven by Kolmogorov–smirnov;

^b By a Bonferroni correction, a p value < 0.00555 was considered significant;

^c During surgery;

^d A parametrical test (student’s t-test) was performed. However, a nonparametrical test (Mann–Whitney U test) was also performed and a P value of 0.004 was obtained.

Abbreviations: EF, ejection fraction; CCr, creatinine clearance; min, minute; ARF, acute renal failure; ICU, intensive care unit.