HbA_1c is associated with severity of obstructive sleep apnea hypopnea syndrome in nondiabetic men

Figures & data

Table 1 Sleep and metabolic characteristics of OSAS patients

Parameter	Mean ±SD	Range
AHI (events/hour)	55.1 ±26.4	15.2–108
Average SpO2 (%)	90 ±5.7	72–95
Minimum SpO2 (%)	71.7 ±12.1	41–88
t < 90 (%)	31.39 ±31.42	0–99
AI (events/hour)	45.1 ±23.3	5–100
Sleep efficiency (%TST)	77.4 ±14.4	34.4–93.9
Sleep latency (minutes)	23.7 ±15.1	5.5–66.5
Stage 1 (%TST)	36.7 ±16.4	9.4–77.1
Stage 2 (%TST)	45.7 ±10.4	25.8–69.1
SWS (%TST)	8 ±9.3	0–38.2
REM (%TST)	12.4 ±5.8	0–24.4
Fasting glucose (mg/dl)	95.1 ±12.5	67–125
HbA1c(%)	5.2 ±0.6	4.2–6.3

Abbreviations: AHI, Apnea Hypopnea Index; AI, Arousal Index; HbA_1c, glycosylated hemoglobin; OSAS, obstructive sleep apnea syndrome; REM, rapid eye motion; SD, standard deviation; SpO₂, saturation of hemoglobin with oxygen as measured by pulse oximetry; SWS, slow-wave sleep; TST, total sleep time.

Figure 1 Correlations of HbA_1c levels with AHI (A), AI (B), average SpO₂ (C) and percentage of sleep time with SpO₂< 90% (D).

Abbreviations: AHI, Apnea Hypopnea Index; AI, Arousal Index; HbA_1c, glycosylated hemoglobin; SpO₂, saturation of hemoglobin with oxygen as measured by pulse oximetry.

Figure 2 Correlations of fasting glucose levels with AHI (A), AI (B), average SpO₂ (C), and minimum SpO₂ (D).

Abbreviations: AHI, Apnea Hypopnea Index; AI, Arousal Index; SpO₂, saturation of hemoglobin with oxygen as measured by pulse oximetry.

Table 2 Results of regression analysis

	Glucose levels
	B ± SD	Beta	P
BMI	0.640 ±0.336	0.339	0.223
AHI	0.092 ±0.095	0.195	0.340
AI	0.196 ±0.094	0.365	0.047
t < 90	12.405 ±7.176	0.312	0.095
Average SpO2	−0.973 ±0.366	−0.442	0.013
Minimum SpO2	−0.419 ±0.179	−0.410	0.027
	HbA1clevels
BMI	0.000 ±0.016	0.006	0.976
AHI	0.011 ±0.004	0.511	0.009
AI	0.011 ±0.004	0.448	0.014
t < 90	0.877 ±0.319	0.470	0.010
Average SpO2	−0.470 ±0.017	−0.456	0.012
Minimum SpO2	−0.015 ±0.09	−0.305	0.112

Abbreviations: AHI, Apnea Hypopnea Index; AI, Arousal Index; BMI, body mass index; SD, standard deviation; SpO₂, saturation of hemoglobin with oxygen as measured by pulse oximetry.