Abstract
Asthma is an inflammatory disorder of the airway. The airway inflammation of asthma is typically an allergic inflammation characterized by cells and mediators described as a ‘Th2’ inflammatory response. There is a growing body of evidence describing changes in the function of immune cells upon aging, a phenomenon referred to as ‘immunosenescence’. Several studies utilizing animal models and human subjects with asthma have begun to explore age-related effects on the airway inflammation that occurs in asthma. This review explores the existing data on the presence and effects of immunosenescence or age-related changes in immune function in asthma.
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Financial & competing interests disclosure
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
No writing assistance was utilized in the production of this manuscript.