Relationship between Inflammatory Parameters and Cardiovascular and Lifestyle Factors in the Mugello Study Oldest Old

Abstract

Aim

To explore possible inter-relationships of various biomarkers of inflammation and lifestyle and other cardiovascular risk factors (age, gender, smoking history, hypertension, Type 2 diabetes, dyslipidemia, alteration of circadian rhythms, body mass index, calf circumference, thigh circumference, abdominal circumference) in the Mugello study oldest old.

Methods

In 399 noninstitutionalized nonagenarians (291 women), whole blood cells, mean platelet volume, C-reactive protein, uric acid, gamma-glutamyl transferase were assessed.

Results

Aging resulted as the only independent determinant for uric acid (<0.05), and abdominal circumference for C-reactive protein. Female gender (<0.01), and thigh circumference (<0.05) remained as determinants for mean platelet volume, age (<0.01), and male gender (<0.01) for gamma-glutamyl transferase, and Type 2 diabetes (≤0.01) and alteration of circadian rhythms (<0.05) for whole blood cells.

Conclusion

Several inflammatory parameters remain associated with adverse lifestyle and cardiovascular risk factors even among nonagenarians.

Graphical abstract

Keywords::

• cardiovascular risk factors
• inflammation
• lifestyle
• nonagenarians
• oldest old
• oxidative stress

Acknowledgements

The Mugello Study Working Group also includes: Roberta Boni, Chiara Castagnoli, Francesca Cecchi, Valentina Fabbri, Roberta Frandi, Annamaria Gori, Silvia Pancani, Anita Paperini, Lorenzo Razzolini, Nona Turcan, Debora Valecchi, Federica Vannetti.

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations. In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved.

Additional information

Funding

The Mugello Study Working Group also includes: Roberta Boni, Chiara Castagnoli, Francesca Cecchi, Valentina Fabbri, Roberta Frandi, Annamaria Gori, Silvia Pancani, Anita Paperini, Lorenzo Razzolini, Nona Turcan, Debora Valecchi, Federica Vannetti.