Myeloperoxidase Activity and Acute Coronary Syndrome Survival: Long-Term Evaluation in The ERICO Study

Abstract

Aim: We aimed to analyze the influence of myeloperoxidase (MPO) activity on mortality in the Acute Coronary Syndrome Registry Strategy (ERICO) study. Methods: MPO activity levels were evaluated in 342 patients. We performed survival analyses using Kaplan–Meier curves and Cox regression with respective hazard ratios, 95% CI, according to MPO tertiles distribution up to 7 years of follow-up. Results: Higher MPO activity levels were seen in men, smokers, diabetics and those who were taking aspirin. MPO activity levels were neither significant in relation to mortality nor to survival rates up to seven years. Conclusion: We found no relationship between elevated levels of MPO activity post-acute coronary syndrome and mortality up to 7-years of follow-up in the ERICO study.

Keywords: :

• acute coronary syndrome
• angina
• inflammation
• mortality
• myeloperoxidase activity
• myocardial infarction
• oxidative stress

Author contributions

AVL Quidim and TC Bruno performed main analyses, wrote the draft and made interpretation and critical revision in the final version of the manuscript regarding to intellectual content. PCL Leocádio and PRL Menta performed main laboratory analyses and interpretation of data and critical revision of the manuscript regarding to intellectual content. JI Alvarez-Leite supervised main laboratory analyses contributed with interpretation of data and critical revision of the manuscript for important intellectual content. IS Santos, PA Lotufo and IM Benseñor were responsible for the data acquisition, conceived and designed the study and were also responsible for the critical revision of the manuscript for important intellectual content and study supervision. AC Goulart was responsible for the data acquisition, conceived and designed the study, was responsible for analysis and interpretation, drafting of the manuscript, critical revision of the manuscript for important intellectual content, statistical analysis, administrative and technical support, study supervision and coordinated directly the manuscript. This article is part of master’s dissertation of Alessandra Vanessa Lopes Quidim by University of São Paulo.

Acknowledgements

The authors want to thank the statistician Airlane Pereira Alencar who collaborated with some analyses in the present manuscript.

Financial & competing interests disclosure

The authors have financial assistance from CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Ethical disclosure

The study protocol was approved by the Institutional Review Board addressing research in human participants. All participants provided written informed consent for the study.

Additional information

Funding

The authors have financial assistance from CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.