Downregulation of Linc00515 in High-Grade Serous Ovarian Cancer and Its Relationship with Platinum Resistance

Abstract

Aim: To investigate the expression of long intergenic noncoding RNA 00515 (LINC00515) in high-grade serous ovarian cancer (HGSOC) and its potential correlation with platinum resistance. Patients & methods: Expression of LINC00515 in HGSOC (n = 115) and normal (n = 19) tissues was detected via quantitative real-time PCR (qRT-PCR). We further explored the statistical significance of the relationship between LINC00515 expression and platinum resistance in HGSOC. Results: LINC00515 was gradually downregulated in the order of normal > platinum-sensitive > platinum-resistant tissue (p < 0.05). Results demonstrated that LINC00515 downregulation was correlated with platinum resistance and relapse-free survival (RFS) of HGSOC (p < 0.05). Conclusion: LINC00515 downregulation is correlated with HGSOC development, platinum resistance and RFS, supporting its utility as a potential biomarker to predict platinum resistance and prognosis of RFS.

Keywords:

• biomarkers
• cancer recurrence
• high-grade serous ovarian cancer
• LINC00515
• long intergenic non-coding RNA
• platinum-based chemotherapy resistance
• qRT-PCR analysis
• relapse-free survival

Financial & competing interests disclosure

This work was supported by a grant from Medical Health Science and Technology Project of Zhejiang Provincial (2017KY266, 2014KYA010 and 2019313304), the National Nature Science Foundation of China (81502603), Natural Science Foundation of Zhejiang Province (LY19H160003). The specimens were supported by Zhejiang Cancer Hospital Biospecimen Repository and National Human Genetic Resource Sharing Service Platform.The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

This study was approved by the Medical Ethics Committee of Zhejiang Cancer Hospital and informed consent was obtained from all subjects.

Additional information

Funding

This work was supported by a grant from Medical Health Science and Technology Project of Zhejiang Provincial (2017KY266, 2014KYA010 and 2019313304), the National Nature Science Foundation of China (81502603), Natural Science Foundation of Zhejiang Province (LY19H160003). The specimens were supported by Zhejiang Cancer Hospital Biospecimen Repository and National Human Genetic Resource Sharing Service Platform.The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.