Downregulation of Reelin Predicts Poor Prognosis for Glioma

Abstract

Aim: In the present study, we studied the relationship between RELN and prognosis in glioma. Materials & methods: Expression profiles and methylation data of RELN were obtained from bioinformatic datasets. Correlations between RELN and clinicopathological features and overall survival were respectively assessed using chi-square test and Kaplan–Meier analysis. Results:RELN was downregulated in glioma, and its downregulation correlated well with glioma malignancy and overall survival. Meanwhile, hypermethylation of RELN was significantly correlated with low RELN expression. Additionally, gene set enrichment analysis demonstrated that low expression of RELN correlated with many key cancer pathways, possibly highlighting the importance of RELN in carcinogenesis of brain. Conclusion:RELN may serve as a potential prognostic marker and promising target molecule for new therapy of glioma.

Keywords:

• bioinformatics
• biomarker
• glioma
• malignancy
• oncology
• overall survival
• prognosis
• reelin (RELN)

Supplementary data

To view the supplementary data that accompany this paper please visit the journal website at: www.tandfonline.com/doi/suppl/10.2217/bmm-2019-0609

Author contributions

Study concept and design were performed by L Jia and A Yao. Acquisition of data was performed by X Li, W Fan, H Song, Y Ge, M Yan, Y Shan, C Zhang and P Li. Analysis and interpretation of data were performed by X Li, W Fan and H Song. Statistical analysis was performed by X Li, W Fan, H Song, Y Ge, M Yan, Y Shan, C Zhang and P Li. Writing of the manuscript was performed by L Jia, X Li and A Yao. All authors approved the manuscript.

Financial & competing interests disclosure

This work was supported by the National Natural Science Foundation of China (grant number 81402455), China Postdoctoral Science Foundation (grant number 2019M653946) and the Key Scientific Research Projects of Higher Education Institutions in Henan Province (grant number 20A310020). The funding sources had no involvement in the design of the study and collection, analysis, or interpretation of data or in writing the manuscript. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The Research Ethics Committee of the General Hospital of PLA and Zhengzhou University reviewed and approved the study according to the principles expressed in the Declaration of Helsinki. The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations.

Additional information

Funding

This work was supported by the National Natural Science Foundation of China (grant number 81402455), China Postdoctoral Science Foundation (grant number 2019M653946) and the Key Scientific Research Projects of Higher Education Institutions in Henan Province (grant number 20A310020). The funding sources had no involvement in the design of the study and collection, analysis, or interpretation of data or in writing the manuscript. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.