Long Noncoding Rnas As Novel Biomarkers for Type 2 Diabetes

Abstract

Type 2 diabetes (T2D) is a metabolic disease characterized by disordered glucagon secretion, insulin resistance in target tissues, and decreased islet β-cell mass and function. The routine diagnosis was based on measurements of metabolic markers, while genetic risk factors have been considered to increase the probability of predicting the development of the disease. Recent evidence suggests that long noncoding RNAs (lncRNAs) regulate gene expression in various physiological and pathological processes. As increasing lncRNAs are identified in β cells, understanding the regulatory roles of lncRNAs in T2D becomes indispensable. In this review, we discuss the potential role of lncRNAs contributing to β-cell identity and T2D susceptibility, which provide a perspective insight into the development of novel diagnosis biomarkers for T2D.

Keywords:

• β-cell
• biomarkers
• long noncoding RNAs (lncRNAs)
• Type 2 diabetes (T2D)

Financial & competing interests disclosure

This article was funded by Important Weak Subject Construction Project of Pudong Health and Family Planning Commission of Shanghai (grant no. PWZbr2017-15). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Additional information

Funding

This article was funded by Important Weak Subject Construction Project of Pudong Health and Family Planning Commission of Shanghai (grant no. PWZbr2017-15). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.