Clinical Potential of Long Non-Coding Rna Linc01133 As A Promising Biomarker and Therapeutic Target in Cancers

Abstract

Recently, long intergenic non-protein coding RNA 01133 (LINC01133) was identified as a novel transcript in cancers. It modulates various hallmarks of cancers and acts as oncogenic in some cancers while tumor-suppressive in others. Furthermore, the expression of LINC01133 correlates with tumor size, advanced tumor node metastasis stage and lymphatic node metastasis, Ki-67 levels and overall survival of patients. Herein, the authors provide an in-depth analysis describing how LINC01133 modulates the multiple cancer-associated signaling pathways and the pathogenesis of various malignancies and treatment regimens. Based on the role played by LINC01133, the authors propose LINC01133 as both a potential biomarker and a therapeutic target in cancer.

Keywords:

• cancer biomarkers
• diagnosis
• LINC01133
• lncRNA
• long non-coding RNA
• prognosis

Author contributions

U Sharma and A Jain conceived the idea. U Sharma, M Murmu, V Acharya and N Pant wrote the majority of the manuscript. D Dey, Vivek and A Gautam composed the figures, and S Bazala, I Singh and TS Barwal created the tables. Critical revisions were made by U Sharma, A Bishayee, TS Barwal and A Jain. All authors read and approved the final manuscript.

Financial & competing interests disclosure

The Department of Science and Technology, India, supported this work through the Indo-Russia grant (INT/RUS/RFBR/P-311) to A Jain and DST-INSPIRE fellowship grant (IF180680) to U Sharma. A Jain is also thankful to the Indian Council of Medical Research (ICMR) for providing grants (5/13/81/2013-NCD-III). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.