Serum Homocysteine Relates to Elevated Lipid Level, Inflammation and Major Adverse Cardiac Event Risk in Acute Myocardial Infarction Patients

Abstract

Aim: This study aimed to evaluate association of homocysteine (Hcy) with major adverse cardiac event (MACE) risk in acute myocardial infarction (AMI). Methods: Serum Hcy data from 196 AMI and 20 angina pectoris patients were retrieved from a hospital's electronic system. AMI patients attended a median of 21.2-month follow-up. Results: Hcy was elevated in AMI patients compared with angina pectoris patients (p = 0.020). In AMI patients, Hcy was positively related to total cholesterol, low-density lipoprotein cholesterol, C-reactive protein, infarct size, TNF-α and IL-6, while inversely linked with IL-10 (all p < 0.05). Hcy was independently associated with high MACE risk in AMI patients (p = 0.024). Conclusion: Serum Hcy correlates with elevated lipid levels, inflammation, infarct size and MACE risk in AMI patients.

Keywords:

• acute myocardial infarction
• homocysteine
• inflammation
• lipid
• major adverse cardiac event

Supplementary data

To view the supplementary data that accompany this paper please visit the journal website at: www.tandfonline.com/doi/suppl/10.2217/bmm-2023-0096

Author contributions

L Ren and J Guo contributed to conception and design. W Zhao, R Zuo, S Guo, C Jia and W Gao contributed to the acquisition and analysis of data. L Ren, W Zhao, R Zuo, S Guo, C Jia and W Gao drafted the article. J Guo revised it critically for important intellectual content. All authors approved the final version to be published.

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations. In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved.