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Epigenomics Volume 7, 2015 - Issue 3
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Review

DNA Methylation as a Diagnostic and Therapeutic Target in the Battle Against Type 2 Diabetes

Tina Rönn1 Epigenetics & Diabetes, Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, CRC, Jan Waldenströms gata 35, 205 02Malmö, SwedenCorrespondence[email protected]
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Charlotte Ling1 Epigenetics & Diabetes, Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, CRC, Jan Waldenströms gata 35, 205 02Malmö, SwedenView further author information
Pages 451-460 | Published online: 16 Jun 2015

Figures & data

Figure 1.  Altered DNA methylation in target tissues for Type 2 diabetes.

Altered DNA methylation and transcriptional activity of Type 2 diabetes candidate genes in human pancreatic islets may contribute to reduced insulin secretion. Additionally, environmental factors may induce insulin resistance in adipose tissue and skeletal muscle through epigenetic modifications.

Figure 1.  Altered DNA methylation in target tissues for Type 2 diabetes. Altered DNA methylation and transcriptional activity of Type 2 diabetes candidate genes in human pancreatic islets may contribute to reduced insulin secretion. Additionally, environmental factors may induce insulin resistance in adipose tissue and skeletal muscle through epigenetic modifications.

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