An Overview of Meningiomas

Abstract

Meningiomas are the most common primary intracranial tumor. Important advances are occurring in meningioma research. These are expected to accelerate, potentially leading to impactful changes on the management of meningiomas in the near and medium term. This review will cover the histo- and molecular pathology of meningiomas, including recent 2016 updates to the WHO classification of CNS tumors. We will discuss clinical and radiographic presentation and therapeutic management. Surgery and radiotherapy, the two longstanding primary therapeutic modalities, will be discussed at length. In addition, data from prior and ongoing investigations of other treatment modalities, including systemic and targeted therapies, will be covered. This review will quickly update the reader on the contemporary management and future directions in meningiomas.

Keywords::

• chemotherapy
• imaging
• meningioma
• molecular pathology
• mutations
• radiotherapy
• stereotactic radiosurgery
• surgery
• targeted therapy
• tumor treating fields

Acknowledgements

The authors acknowledge I Gardner of UCSF for copyright assistance.

Financial & competing interests disclosure

This work is supported by P50CA221747 SPORE for Translational Approaches to Brain Cancer (CM Horbinski, CD James, RV Lukas). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Additional information

Funding

This work is supported by P50CA221747 SPORE for Translational Approaches to Brain Cancer (CM Horbinski, CD James, RV Lukas). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.