Abstract
Aim: To explore the impact of preoperative the albumin-to-globulin ratio (AGR) and the prognostic nutritional index (PNI) on prognosis in rectal mucinous adenocarcinoma (MAC). Methods: A total of 128 patients were included. Results: According to the X-tile analysis, cutoff values of AGR and PNI were 1.1 and 43.8. Preoperative AGR (p = 0.041), preoperative PNI (p = 0.036) and pTNM stage (p = 0.003) were independently associated with overall survival in rectal MAC patients. Distance from the anal verge (p = 0.005), preoperative AGR (p = 0.021), preoperative PNI (p = 0.007) and pTNM stage (p < 0.001) were significantly associated with disease-free survival in rectal MAC patients. Nomograms for overall survival and disease-free survival were developed (C-index: 0.739 and 0.764). Conclusion: Preoperative AGR and PNI can act as effective predictors for survival for rectal MAC patients.
Supplementary data
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Authors’ contributions
Y Sun and P Chi designed the study. Y Sun and Z Huang collected the data and were major contributors in writing the manuscript and interpretation of the work. All the authors read and approved the final manuscript.
Financial & competing interests disclosure
This study was supported by Construction Project of Fujian Province Minimally Invasive Medical Center (grant number: [2017]171), Startup Fund for Scientific Research, Fujian Medical University (grant number: 2017XQ1028), Joint Funds for the Innovation of Science and Technology, Fujian province (grant number: 2018Y9030) and Young and Middle-aged Backbone Training Project in the Health System of Fujian province (grant number: 2019-ZQN-45). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.
Ethical conduct of research
The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations. In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved.