Lung cancer patients with anaplastic lymphoma kinase rearrangement lose affiliation with labor market at diagnosis

Figures & data

Figure 1. CONSORT diagram for ALK+ NSCLC patients included in the study.

Table 1. Baseline characteristics of the ALK-cohort.

Characteristics	n = 209, n (%)
Gender:
– Male	91 (43.5)
– Female	118 (56.5)
Age (years):
– Mean (standard deviation)	61.6 (14.2)
– Median	64.6
Cancer stage at time of diagnosis:
– I–IIIA	58 (28)
– IIIB–IVB	146 (70)
– Unknown/missing	5 (2)

Figure 2. Overall survival and incidence and prevalence of ALK+ NSCLC in Denmark.

(A) Overall survival of the ALK+ NSCLC patient group. Dotted lines represent 95% CIs. (B) Incidence and prevalence of ALK+ NSCLC patients in Denmark from 2012 to 2018. Square represents: 1-year prevalence. Triangles pointing up and down represents 3- and 5-year prevalence, respectively. Closed circles represent annual incidence. All values are cases/million Danes.

Figure 3. Labor market affiliation of working age (≤60 years of age) control group and ALK+ NSCLC survivors 6 months before diagnosis, at diagnosis, 6, 12 and 18 months following diagnosis.

Labor market affiliation is classified into three categories: 1) employed (full- or part-time; black bar), 2) subsidized (receiving unemployment benefits, unemployment educational benefits and sick leave benefits; light gray bar), and 3) retirees (receiving retirement and early retirement benefits; dark grey bars).

^†Data on retirement were not shown for these data points as fewer than five individuals were retired among the ALK+ NSCLC patients.

Table 2. Overview of labor market affiliations (employed, subsidized, or retired) for ALK+ NSCLC patients and control survivors ≤60 years of age.

Labor market affiliation of survivors	-6 months		At diagnosis		6 months		12 months		18 months
	n	%	n	%	n	%	n	%	n	%
ALK+ NSCLC (n = 75)
In employment	61	81%	32	43%	18	26%	24	36%	21	36%
Subsidized	14	19%	43	57%	43	62%	32	48%	28	48%
Retired	<5	<5	<5	<5	8	12%	10	15%	9	15%
Control group (n = 748)
In employment	606	81%	605	81%	591	79%	603	81%	586	80%
Subsidized	95	13%	95	13%	102	14%	88	12%	95	13%
Retired	47	6%	48	6%	55	7%	50	7%	51	7%

Subjects were censored from the labor market affiliation analysis if they died or left the country. Note that absolute values less than 5 are not reported due to Danish data protection laws.

Table 3. Overview of labor market affiliations (employed, subsidized, retired, or dead/left the country) for ALK+ NSCLC patients and control subjects ≤60 years of age.

Labor market affiliation and survivorship of study populations	-6 months		At diagnosis		6 months		12 months		18 months
	n	%	n	%	n	%	n	%	n	%
ALK+ NSCLC (n = 75)
In employment	61	81%	32	43%	18	24%	24	32%	21	28%
Subsidized	14	19%	43	57%	43	57%	32	43%	28	37%
Retired	<5	<5	<5	<5	8	11%	10	13%	9	12%
Died or left the country	0	0	0	0	6	8%	9	12%	17	23%
Control group (n = 748)
In employment	606	81%	605	81%	591	79%	603	81%	586	78%
Subsidized	95	13%	95	13%	102	14%	88	12%	95	13%
Retired	47	6%	48	6%	55	7%	50	7%	51	7%
Died or left the country	0	0	0	0	<5	<5	7	1%	16	2%

Subjects were not censored from the labor market affiliation analysis if they died or left the country. Note that absolute values less than 5 are not reported due to Danish data protection laws.