Primary Malignant Melanoma of the Genitourinary Tract: Case Series of a Rare Form of Primary Mucosal Melanoma

Figures & data

Figure 1. CT intravenous pyelogram (coronal and axial views) of polypoid urinary bladder mass.

(A & B) CT intravenous pyelogram (coronal and axial views) showing polypoid soft tissue mass at the lower aspect of the urinary bladder measuring 3.3 × 3.1 × 2.4 cm compatible with the biopsy-proven malignant melanoma.

Figure 2. Gross image of 4.0 × 3.0 × 2.5 cm polypoid inferior bladder mass with proximal urethral involvement and multifocal melanosis.

Figure 3. Robotic-assisted laparascopic cystourethrectomy of urinary bladder showing sheets of highly atypical melanoma cells.

(A & B) Robotic-assisted laparoscopic radical cystourethrectomy showing sheets of highly atypical dyscohesive melanoma cells in the urinary bladder 10× (left), tumor cells demonstrate positivity for SOX10 (right).

Figure 4. Robotic-assisted laparascopic cystourethrectomy of urinary bladder showing pagetoid spread of melanoma cells.

(A & B) Robotic-assisted laparoscopic radical cystourethrectomy showing the pagetoid spread of melanoma to the urethra (left), tumor cells demonstrate positivity for SOX10 (right).

Figure 5. Robotic-assisted laparascopic cystourethrectomy of urinary bladder showing melanoma in situ.

(A & B) Robotic-assisted laparoscopic radical cystourethrectomy showing primary malignant melanoma of the urinary bladder with melanoma in-situ (left), specimen stains positive for SOX 10 (right).

Figure 6. MRI pelvis (coronal and axial views) of nodular enhancing urinary bladder mass.

(A & B) MRI pelvis (coronal and axial views) showing nodular enhancing soft tissue mass at the posterior segment of the urethra and urinary bladder base measuring 1.7 × 1.5 × 0.9 cm compatible with the biopsy-proven malignant melanoma.

Figure 7. Radical cystourethrectomy showing pagetoid spread to the distal urethral margin.

(A & B) Radical cystourethrectomy showing atypical melanoma cells of the urinary bladder with pagetoid spread of melanoma to the distal urethral margin.5× (left), tumor cells demonstrate positivity for SOX10 (right).

Figure 8. Radical cystourethrectomy showing highly atypical epithelioid melanoma cells.

(A & B) Radical cystourethrectomy showing highly atypical epithelioid melanoma cells of the urinary bladder 40× (left), tumor cells demonstrate positivity for SOX10 (right).

Figure 9. Radical cystourethrectomy showing atypical melanoma cells.

(A & B) Radical cystourethrectomy showing atypical melanoma cells in the urinary bladder diffusely involving the submucosa and muscularis propria with corresponding urothelium uninvolved 1× (left), tumor cells demonstrate positivity for SOX10 (right).