SLCO1B3 T334G Polymorphisms and Mycophenolate Mofetil-Related Adverse Reactions in Kidney Transplant Recipients

Abstract

Background: The correlation between SLCO1B3 T334G polymorphisms and mycophenolate mofetil (MMF) adverse reactions in kidney recipients is unknown. Methods: A single-center, retrospective study was performed in which 111 patients were divided into four groups according to the type of adverse effect experienced. The clinical data and concentrations of MMF at different months after transplantation were statistically analyzed. Results: The G allele in the gastrointestinal reaction group was significantly higher than that in the no adverse effects group (p < 0.05). Logistic regression model showed that the SLCO1B3 T334G genotype was an independent risk factor for gastrointestinal reactions caused by MMF. Conclusion: Patients with the SLCO1B3 T334G GG genotype were more likely to experience gastrointestinal reactions.

Keywords::

• adverse effects
• gene polymorphism
• kidney transplantation
• mycophenolate mofetil
• SLCO1B3 T334G

Financial & competing interests disclosure

This study was supported by the National Natural Science Foundation of China (grant no. 82002252) and Discipline Cultivation Funding, Zhongnan Hospital of Wuhan University (grant no. ZNXKPY2021033). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations. In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved.

Additional information

Funding

This study was supported by the National Natural Science Foundation of China (grant no. 82002252) and Discipline Cultivation Funding, Zhongnan Hospital of Wuhan University (grant no. ZNXKPY2021033). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.