Association of TNF-α Polymorphism with Prediction of Response to TNF Blockers in Spondyloarthritis and Inflammatory Bowel Disease: A Meta-Analysis

Abstract

Aim: To explore whether TNF-α promoter -308 A/G and -857 C/T polymorphisms have an association with responsiveness to TNF blockers in spondyloarthritis and inflammatory bowel disease. Methods: A meta-analysis was performed. Pooled odds ratios (ORs) and 95% CIs were calculated. Results: Six relevant studies with a total of 211 spondyloarthritis patients and 392 inflammatory bowel disease patients were included. The results showed that the common allele (G and C, respectively) showed a better responsiveness than the minor allele (A and T, respectively). The -308 G/G genotype (OR: 2.31; 95% CI: 1.36–3.91; p = 0.002) and -857 C/C genotype (OR: 3.66; 95% CI: 1.35–9.92; p = 0.01) responded better to therapy, which was different from the results of some studies included. Conclusion: Individuals with the TNF-α-308 G allele and -857 C allele showed better anti-TNF-α treatment responses than those with the TNF-α-308 A allele and -857 T allele. The -308 G/G genotype and -857 C/C genotype are predictors of good response.

Original submitted 30 May 2013; Revised submitted 25 July 2013

KEYWORDS::

• inflammatory bowel disease
• meta-analysis
• prediction
• spondyloarthritis
• TNF blocker
• TNF-α-308 polymorphism
• TNF-α-857 polymorphism

Acknowledgements

The authors would like to extend their gratitude to Shanghai Scientific Committee Basic Research Fund for their financial support. The authors would like to thank P Bajracharya from Shree Birendra Military hospital, Nepal for her help in revising the article. The authors would like to thank Director H Jia from the Department of Statistics for her support in their analysis. Finally, the authors wish to acknowledge all the colleagues in their department for their assistance and encouragement.

Financial & competing interests disclosure

This study has been supported by grants from Shanghai Scientific Committee Basic Research Fund (08JC1406300, 08JC1406200). This study was also supported by grants from National Natural Science Foundation of China (NSFC; H1008,81302580) and National Key Basic Research Program of China (973) Program (2014CB541804). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations. In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved.

Additional information

Funding

This study has been supported by grants from Shanghai Scientific Committee Basic Research Fund (08JC1406300, 08JC1406200). This study was also supported by grants from National Natural Science Foundation of China (NSFC; H1008,81302580) and National Key Basic Research Program of China (973) Program (2014CB541804). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.